Transcription inhibitors prevent amnesia induced by NMDA antagonist-mediated impairment of memory reconsolidation

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• 作者：Vladimir P. Nikitin ; Svetlana V. Solntseva ; Alexey V. Shevelkin
• 关键词：Amnesia ; Transcription inhibitor ; NMDA glutamate receptor antagonist ; Learning ; Conditioned food aversion ; Long ; term memory ; Reconsolidation ; Snail ; Helix lucorum
• 刊名：Learning & Behavior
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：44
• 期：3
• 页码：250-259
• 全文大小：694 KB
• 刊物主题：Psychology, general; Neurosciences;
• 出版者：Springer US
• ISSN：1543-4508
• 卷排序：44

文摘

Recent studies report that long-term memory retrieval can induce memory reconsolidation, and impairment of this reconsolidation might lead to amnesia. Previously, we found that reconsolidation of a conditioned food aversion memory could be disrupted by translation inhibitors for up to 3 h following a reconsolidation event, thus inducing amnesia. We examined the role of transcription processes in the induction of amnesia in the land snail, Helix lucorum. It received N-methyl-D-aspartate (NMDA) glutamate receptor antagonist and transcription inhibitor 2 days after learning in a neutral context environment; it was then transferred to the learning context followed by reminder with conditioned food stimulus. NMDA receptor blockade, followed by a reminder session, impaired reconsolidation of an aversive memory. Simultaneous administration of an NMDA receptor antagonist and a transcription inhibitor prior to reminder of an aversive event prevented amnesia induction. In contrast, when a transcription inhibitor alone was injected prior to a reminder session, the blockade had no effect on memory. We found that transcription inhibition 0−6 h after amnesia induction suppressed memory loss, but this suppression was lost when inhibitors were administered 9 h after amnesia. Thus, amnesia is likely dependent on transcription processes within a 9-h time window. We can hypothesize that amnesia induction initiates synthesis of specific mRNAs and proteins; furthermore, these events occur within specific time-dependent windows. Our findings could prove useful for the analysis of amnesia formation and for the development of possible ways to prevent memory loss associated with various diseases and injuries in animals and humans.