Differential changes in gingival somatosensory sensitivity after painful electrical tooth stimulation

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• 作者：Lene Baad-Hansen ; Shengyi Lu ; Pentti Kemppainen ; Thomas List…
• 关键词：Quantitative sensory testing ; Painful tooth stimulation ; Somatosensory sensitivity ; Heterotopic changes in sensitivity
• 刊名：Experimental Brain Research
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：233
• 期：4
• 页码：1109-1118
• 全文大小：670 KB
• 参考文献：1. Avellan, NL, Sorsa, T, Tervahartiala, T, Mantyla, P, Forster, C, Kemppainen, P (2005) Painful tooth stimulation elevates matrix metalloproteinase-8 levels locally in human gingival crevicular fluid. J Dent Res 84: pp. 335-339 CrossRef
  2. Avellan, NL, Sorsa, T, Tervahartiala, T, Forster, C, Kemppainen, P (2008) Experimental tooth pain elevates substance P and matrix metalloproteinase-8 levels in human gingival crevice fluid. Acta Odontol Scand 66: pp. 18-22 CrossRef
  3. Baad-Hansen, L (2008) Atypical odontalgia—pathophysiology and clinical management. J Oral Rehabil 35: pp. 1-11 CrossRef
  4. Baad-Hansen, L, Leijon, G, Svensson, P, List, T (2008) Comparison of clinical findings and psychosocial factors in patients with atypical odontalgia and temporomandibular disorders. J Orofac Pain 22: pp. 7-14
  5. Baad-Hansen, L, Pigg, M, Ivanovic, SE, Faris, H, List, T, Drangsholt, M, Svensson, P (2013) Chairside intraoral qualitative somatosensory testing: reliability and comparison between patients with atypical odontalgia and healthy controls. J Orofac Pain 27: pp. 165-170 CrossRef
  6. Baad-Hansen, L, Pigg, M, Ivanovic, SE, Faris, H, List, T, Drangsholt, M, Svensson, P (2013) Intraoral somatosensory abnormalities in patients with atypical odontalgia-a controlled multicenter quantitative sensory testing study. Pain 154: pp. 1287-1294 CrossRef
  7. Baad-Hansen L, Pigg M, Yang G, List T, Svensson P, Drangsholt M (2014) Reliability of intra-oral quantitative sensory testing (QST) in patients with atypical odontalgia and healthy controls—a multicentre study. J Oral Rehabil. doi:10.1111/joor.12245
  8. Benoliel, R, Zadik, Y, Eliav, E, Sharav, Y (2012) Peripheral painful traumatic trigeminal neuropathy: clinical features in 91 cases and proposal of novel diagnostic criteria. J Orofac Pain 26: pp. 49-58
  9. Brown, AC, Beeler, WJ, Kloka, AC, Fields, RW (1985) Spatial summation of pre-pain and pain in human teeth. Pain 21: pp. 1-16 CrossRef
  10. Chiang, CY, Park, SJ, Kwan, CL, Hu, JW, Sessle, BJ (1998) NMDA receptor mechanisms contribute to neuroplasticity induced in caudalis nociceptive neurons by tooth pulp stimulation. J Neurophysiol 80: pp. 2621-2631
  11. Col, R, Maih?fner, C (2008) Centrally mediated sensory decline induced by differential C-fiber stimulation. Pain 138: pp. 556-564 CrossRef
  12. Forssell H, J??skel?inen S, List T, Svensson P, Baad-Hansen L (2014) An update on pathophysiological mechanisms related to idiopathic orofacial pain conditions with implications for management. J Oral Rehabil. doi:10.1111/joor.12256
  13. Gracely, RH, Dubner, R, McGrath, PA (1979) Narcotic analgesia: fentanyl reduces the intensity but not the unpleasantness of painful tooth pulp sensations. Science 203: pp. 1261-1263 CrossRef
  14. Gracely, RH, Dubner, R, McGrath, PA (1982) Fentanyl reduces the intensity of painful tooth pulp sensations: controlling for detection of active drugs. Anesth Analg 61: pp. 751-755
  15. Holzer, P (1988) Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24: pp. 739-768 CrossRef
  16. Hu, JW, Sessle, BJ (1989) Effects of tooth pulp deafferentation on nociceptive and nonnociceptive neurons of the feline trigeminal subnucleus caudalis (medullary dorsal horn). J Neurophysiol 61: pp. 1197-1206
  17. Hu, JW, Dostrovsky, JO, Lenz, YE, Ball, GJ, Sessle, BJ (1986) Tooth pulp deafferentation is associated with functional alterations in the properties of neurons in the trigeminal spinal tract nucleus. J Neurophysiol 56: pp. 1650-1668
  18. Hu, JW, Sharav, Y, Sessle, BJ (1990) Effects of one- or two-stage deafferentation of mandibular and maxillary tooth pulps on the functional pro
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1106

文摘

We aimed to evaluate the effect of painful tooth stimulation on gingival somatosensory sensitivity of healthy volunteers in a randomized, controlled design. Thirteen healthy volunteers (six women, seven men; 28.4?±?5.0?years) were included for two experimental sessions of electrical tooth stimulation: painful tooth stimulation and tooth stimulation below the sensory threshold (control). Eight of the human subjects participated in a third session without tooth stimulation. In all sessions, the somatosensory sensitivity of the gingiva adjacent to the stimulated tooth was evaluated with a standardized battery of quantitative sensory tests (QST) before, immediately after and 30?min after tooth stimulation. Painful tooth stimulation evoked significant decreases in warmth and heat pain thresholds (P?P?=?0.024) and increases in mechanical detection thresholds (decreased sensitivity) (P?P?P?>?0.086). No QST changes were detected in the session without tooth stimulation (P?>?0.060). In conclusion, modest increased gingival sensitivity to warmth, painful heat and pressure stimuli as well as desensitization to non-painful mechanical stimulation were demonstrated after tooth stimulation. This suggests involvement of competing heterotopic facilitatory and inhibitory mechanisms. Furthermore, stimulation below the sensory threshold induced similar thermal sensitization suggesting the possibility of activation of axon-reflex-like mechanisms even at intensities below the perception threshold. These findings may have implications for interpretation of somatosensory results in patients with chronic intraoral pain.