Thermosensitive Transient Receptor Potential (TRP) Channel Agonists and Their Role in Mechanical, Thermal and Nociceptive Sensations as Assessed Using Animal Models

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• 作者：A. H. Klein ; Minh Trannyguen ; Christopher L. Joe…
• 关键词：Eugenol ; Carvacrol ; TRPV3 ; TRPV1 ; TRPA1 ; TRPM8 ; Pain ; Temperature ; Touch
• 刊名：Chemosensory Perception
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：8
• 期：2
• 页码：96-108
• 全文大小：526 KB
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• 作者单位：A. H. Klein (1)
  Minh Trannyguen (2)
  Christopher L. Joe (2)
  M. Iodi Carstens (2)
  E. Carstens (2)
  
  1. Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, 21287, USA
  2. Department of Neurobiology, Physiology, and Behavior, University of California, Davis, 1 Shields Avenue, Davis, CA, 95616, USA
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Food Science
  Chemistry
  Neurosciences
  
• 出版者：Springer New York
• ISSN：1936-5810

文摘

Introduction The present paper summarizes research using animal models to investigate the roles of thermosensitive transient receptor potential (TRP) channels in somatosensory functions including touch, temperature, and pain. We present new data assessing the effects of eugenol and carvacrol, agonists of the warmth-sensitive TRPV3, on thermal, mechanical, and pain sensitivity in rats.