Molecular mechanisms of action of quercetin in cancer: recent advances
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- 作者：Dharambir Kashyap ; Sonam Mittal ; Katrin Sak ; Paavan Singhal…
- 关键词：Quercetin ; Apoptosis ; Cell cycle ; Anti ; angiogenesis ; Anti ; metastasis ; Toxicity
- 刊名：Tumor Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：37
- 期：10
- 页码：12927-12939
- 全文大小：1,256 KB
- 刊物主题：Cancer Research;
- 出版者：Springer Netherlands
- ISSN：1423-0380
- 卷排序：37
文摘
In the last few decades, the scientific community has discovered an immense potential of natural compounds in the treatment of dreadful diseases such as cancer. Besides the availability of a variety of natural bioactive molecules, efficacious cancer therapy still needs to be developed. So, to design an efficacious cancer treatment strategy, it is essential to understand the interactions of natural molecules with their respective cellular targets. Quercetin (Quer) is a naturally occurring flavonol present in many commonly consumed food items. It governs numerous intracellular targets, including the proteins involved in apoptosis, cell cycle, detoxification, antioxidant replication, and angiogenesis. The weight of available synergistic studies vigorously fortifies the utilization of Quer as a chemoprevention drug. This extensive review covers various therapeutic interactions of Quer with their recognized cellular targets involved in cancer treatment.