Novel group-based QSAR and combinatorial design of CK-1δ inhibitors as neuroprotective agents
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- 作者：Kopal Joshi ; Sukriti Goyal ; Sonam Grover ; Salma Jamal ; Aditi Singh…
- 关键词：Amyotrophic lateral sclerosis ; ALS ; TDP ; 43 ; Casein kinase ; QSAR ; Combinatorial library
- 刊名：BMC Bioinformatics
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：19-supp
- 全文大小：1354KB
- 刊物主题：Bioinformatics; Microarrays; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Algorithms;
- 出版者：BioMed Central
- ISSN：1471-2105
- 卷排序：17
文摘
BackgroundTar DNA binding protein 43 (TDP-43) hyperphosphorylation, caused by Casein kinase 1 (CK-1) protein isoforms, is associated with the onset and progression of Amyotrophic Lateral Sclerosis (ALS). Among the reported isoforms and splice variants of CK-1 protein superfamily, CK-1δ is known to phosphorylate different serine and threonine sites on TDP-43 protein in vitro and thus qualifies as a potential target for ALS treatment.