Enhanced Expression of Resistin-like Molecule Beta in Human Colon Cancer and Its Clinical Significance

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• 作者：Li-Duan Zheng ; Qiang-Song Tong ; Mi-Xia Weng ; Jun He ; Qing Lv ; Jia-Rui Pu ; Guo-Song Jiang ; Jia-Bin Cai ; Yuan Liu and Xiao-Hua Hou
• 关键词：Resistin ; like molecule beta ; Colon cancer ; Immunohistochemistry
• 刊名：Digestive Diseases and Sciences
• 出版年：2009
• 出版时间：February, 2009
• 年：2009
• 卷：54
• 期：2
• 页码：274-281
• 全文大小：389.6 KB

文摘

Previous studies have indicated that resistin-like molecule beta (RELMβ), an intestinal goblet cell-specific protein, is markedly increased in the intestinal tumors of min mice and over-expressed in a human colon cancer cell line. We hypothesized that RELMβ might be enhanced in human colon cancer. The aim of this study was to examine the clinical importance of RELMβ expression in colon cancer patients and to correlate its expression with various clinicopathological parameters, upstream regulatory molecule expression, tumor proliferative capacity, and patients’ survival. Of the 80 colon cancer patients studied, 65 (81.25 % ) tested positive for RELMβ, mainly in the cytoplasm of colon mucosa. Contrasting sharply with the strongly RELMβ-positive tumors, normal colon mucous membrane was negative or weakly positive. RELMβ positivity in colon cancer was correlated with histological grade of differentiation and lymph node metastasis, but not with age, gender, tumor location and size, tumor infiltration, Dukes’ stage, liver metastasis, and venous invasion. RELMβ expression was significantly correlated with the expression of transcription factor CDX-2 (P < 0.01) but not with that of proliferative index Ki-67 (P > 0.05). The mean postoperative survival time (2.76 years) of RELMβ-positive patients was significantly longer than that (1.26 years) of RELMβ-negative patients (P = 0.032). These findings support evidence of the enhanced RELMβ expression in colon cancer patients and suggest that further investigation is warranted to explore the role of RELMβ in colon cancer.