Safety of using Escherichia coli bacteriophages as a sanitizing agent based on inflammatory responses in rats
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  • 作者:Ji-Yeon Hwang ; Jung-Eun Kim ; Yoon-Jae Song
  • 关键词:E. coli bacteriophage ; pro ; inflammatory cytokine ; phage ; fed rat
  • 刊名:Food Science and Biotechnology
  • 出版年:2016
  • 出版时间:February 2016
  • 年:2016
  • 卷:25
  • 期:1
  • 页码:355-360
  • 全文大小:472 KB
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  • 作者单位:Ji-Yeon Hwang (1)
    Jung-Eun Kim (2)
    Yoon-Jae Song (2)
    Jong-Hyun Park (1)

    1. Department of Food Science and Biotechnology, Gachon University, Seongnam, Gyeonggi, 13120, Korea
    2. Department of Life Science, Gachon University, Seongnam, Gyeonggi, 13120, Korea
  • 刊物类别:Chemistry and Materials Science
  • 刊物主题:Chemistry
    Nutrition
    Food Science
  • 出版者:The Korean Society of Food Science and Technology in co-publication with Springer
  • ISSN:2092-6456
文摘
Use of bacteriophages as sanitizing agents has received much attention. However, safety in humans is debatable. To determine inflammatory immune responses against bacteriophages, rats were treated with a 8 log plaque-forming cocktail of 5 bacteriophages for pathogenic Escherichia coli per day for 4 weeks. Food consumption, feeding efficiency, and body weight of rats treated with the cocktail were not different from controls. Phages were not detected in the sera of phage-fed rats with no changes in organ weights. Notable changes were not observed upon histopathological examination of the liver, kidney, and spleen. Pro-inflammatory cytokine mRNA expression, except COX-2 (2.4x increase), remained unaffected after treatment with the phage cocktail. No remarkable changes were observed for levels of 12 pro-inflammatory cytokines in sera. Inflammatory responses in rats orally treated with a phage cocktail were not observed. Bacteriophages for E. coli are indicated as immunologically safe in rats.

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