The hypoglycemic effect of fermented Pueraria thunbergiana extract in streptozotocin-induced diabetic mice
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- 作者：Mi-Hwa Park ; Ji-Hye Kang ; Ji-Sook Han
- 关键词：fermented Pueraria thunbergiana ; α ; glucosidase ; α ; amylase ; postprandial hyperglycemia ; diabetic mice
- 刊名：Food Science and Biotechnology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：24
- 期：6
- 页码：2199-2203
- 全文大小：308 KB
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25.Kim KY, Nam KA, Kurihara H, Kim SM. Potent a-glucosid - 作者单位：Mi-Hwa Park (1)
Ji-Hye Kang (2)
Ji-Sook Han (3)
1. Department of Food and Nutrition, College of Medical and Life Science, Silla University, Busan, 46958, Korea
2. Department of Food Science and Nutrition, Pusan National University, Busan, 46141, Korea
3. Department of Food Science and Nutrition & Research Institute of Ecology for the Elderly, Pusan National University, Busan, 46141, Korea - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Nutrition
Food Science - 出版者：The Korean Society of Food Science and Technology in co-publication with Springer
- ISSN：2092-6456
文摘
This study investigated the effect of fermented and non-fermented Pueraria thunbergiana extract (FPE and PE, respectively) on postprandial hyperglycemia in streptozotocin-induced diabetic mice. FPE was prepared by fermentation of P. thunbergiana with Bifidobacterium breve K-111 followed by methanol extraction. FPE’s inhibitory activity against α-glucosidase and α-amylase was significantly higher than that of PE with IC50 values of 0.15 and 0.10 and 0.23 and 0.44 mg/mL for FPE and PE, respectively. The increase in postprandial blood glucose levels was significantly higher in FPE- than in PE-treated diabetic mice. Furthermore, FPE significantly lowered the incremental area under the curve (AUC) in the diabetic mice; the AUC in the normal mice corroborated FPE’s hypoglycemic effect. The results from this study suggest that FPE, more than PE, may help decrease postprandial hyperglycemia by inhibiting α-glucosidase and a-amylase. Keywords fermented Pueraria thunbergiana α-glucosidase α-amylase postprandial hyperglycemia diabetic mice