Incidence of medulloblastoma in Canadian children

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• 作者：Donna L. Johnston (1)
  Daniel Keene (2)
  Maria Kostova (1)
  Douglas Strother (3)
  Lucie Lafay-Cousin (3)
  Chris Fryer (4)
  Katrin Scheinemann (5)
  Anne-Sophie Carret (6)
  Adam Fleming (7)
  Vanessa Percy (8)
  Samina Afzal (9)
  Beverly Wilson (10)
  Lynette Bowes (11)
  Shayna Zelcer (12)
  Chris Mpofu (13)
  Mariana Silva (14)
  Valerie Larouche (15)
  Josee Brossard (16)
  Eric Bouffet (17)
  
• 关键词：Medulloblastoma ; Incidence ; Pediatrics ; Canada
• 刊名：Journal of Neuro-Oncology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：120
• 期：3
• 页码：575-579
• 全文大小：597 KB
• 参考文献：1. Fisher PG (2004) Embryonal tumors. In: Gupta N, Banerjee A, Haas-Kogan D (eds) Pediatric CNS Tumors. Springer, New York, pp 83-05 CrossRef
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  4. McNeil DE, Cote TR, Clegg L, Rorke LB (2002) Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: a SEER update. Med Pediatr Oncol 39:190-94 CrossRef
  5. McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M, Tihan T, Preston-Martin S (2013) Trends in childhood brain tumor incidence, 1973-009. J Neurooncol 115:153-60 CrossRef
  6. Partap S, Curran EK, Propp JM, Le GM, Sainani KL, Fisher PG (2009) Medulloblastoma incidence has not changed over time. A CBTRUS study. J Pediatr Hematol Oncol 31:970-71 CrossRef
  7. Morland BJ, Parkes SE (1995) Decline in incidence of medulloblastoma in children. Cancer 76:155-56 CrossRef
  8. Smoll NR, Drummond KJ (2012) The incidence of medulloblastomas and primitive neuroectodermal tumours in adults and children. J Clin Neurosci 19:1541-544 CrossRef
  9. Alexiou GA, Moschovi M, Stafanaki K, Sfakianos G, Prodromou N (2011) Epidemiology of pediatric brain tumors in Greece (1991-008). Experience from the “Agia Sofia-Children’s Hospital. Cent Eur Neurosurg 72:1- CrossRef
  
• 作者单位：Donna L. Johnston (1)
  Daniel Keene (2)
  Maria Kostova (1)
  Douglas Strother (3)
  Lucie Lafay-Cousin (3)
  Chris Fryer (4)
  Katrin Scheinemann (5)
  Anne-Sophie Carret (6)
  Adam Fleming (7)
  Vanessa Percy (8)
  Samina Afzal (9)
  Beverly Wilson (10)
  Lynette Bowes (11)
  Shayna Zelcer (12)
  Chris Mpofu (13)
  Mariana Silva (14)
  Valerie Larouche (15)
  Josee Brossard (16)
  Eric Bouffet (17)
  
  1. Division of Pediatric Hematology/Oncology, Children’s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada
  2. Division of Pediatric Neurology, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada
  3. Section of Pediatric Oncology and Blood and Marrow Transplantation, University of Calgary, Calgary, AB, Canada
  4. Division of Pediatric Hematology/Oncology, British Columbia Children’s Hospital, Vancouver, BC, Canada
  5. Division of Pediatric Hematology/Oncology, McMaster Children’s Hospital, Hamilton, ON, Canada
  6. Division of Pediatric Hematology/Oncology, St Justine Hospital, Montreal, QC, Canada
  7. Division of Pediatric Hematology/Oncology, Montreal Children’s Hospital, Montreal, QC, Canada
  8. Division of Pediatrics, CancerCare Manitoba, Winnipeg, MB, Canada
  9. Division of Pediatric Hematology/Oncology, IWK Children’s Hospital, Halifax, NS, Canada
  10. Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, Edmonton, AB, Canada
  11. Division of Pediatric Hematology/Oncology, Janeway Children’s Hospital, St. John’s, NL, Canada
  12. Division of Pediatric Hematology/Oncology, Children’s Hospital of Western Ontario, London, ON, Canada
  13. Division of Pediatric Hematology/Oncology, Saskatoon Children’s Hospital, Saskatoon, SK, Canada
  14. Division of Pediatric Hematology/Oncology, Kingston General Hospital, Kingston, ON, Canada
  15. Division of Pediatric Hematology/Oncology, Centre Hospitalier Universitaire de Quebec, Quebec, QC, Canada
  16. Division of Pediatric Hematology/Oncology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
  17. Division of Pediatric Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada
  
• ISSN：1573-7373

文摘

Medulloblastoma is the most common malignant brain tumor in children. There was a perception of pediatric neuro-oncologists that the incidence had declined in Canada. An epidemiological survey was undertaken to determine the incidence of this tumor in Canada and if a change had indeed occurred. All patients 14?years and under diagnosed with medulloblastoma from 1990 to 2009 inclusive in Canada were included. Data collected included date of diagnosis, age at diagnosis, gender, stage, pathology, treatment, recurrence and current status. Data were analysed for change in incidence over time. Data were obtained on 574 eligible patients. The mean overall incidence per 1,000,000 persons was 4.82 (95?% CI 4.28-.35) for the study time period. The mean age at diagnosis was 5.8?years, and there was a male predominance. Although there was an increase in incidence over the first three time periods (24?% for 1990-994, 27.5?% for 1995-999, 27.7?% for 2000-004), the most recent time period (2005-009) showed a decrease (21?%). This was true for male children while the incidence was stable for females. The mean incidence rate was double for children under the age of 5?years (7.92 per million) compared to those over 5?years (3.64 per million).This study showed that from 1990 to 2009 the incidence of medulloblastoma was relatively stable, with a slight decrease in the last five-year time period.