Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid
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- 作者：Soraya Wilke Saliba ; Erica Leandro Marciano Vieira…
- 关键词：Neurodegeneration ; mTOR ; Rapamycin ; Quinolinic acid ; Inflammation ; Glutamate ; Neurotrophic factors
- 刊名：Journal of Neuroinflammation
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：5680KB
- 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
- 出版者：BioMed Central
- ISSN：1742-2094
- 卷排序：14
文摘
BackgroundThe mammalian target of rapamycin (mTOR) is a kinase involved in a variety of physiological and pathological functions. However, the exact role of mTOR in excitotoxicity is poorly understood. Here, we investigated the effects of mTOR inhibition with rapamycin against neurodegeneration, and motor impairment, as well as inflammatory profile caused by an excitotoxic stimulus.