Trogocytic intercellular membrane exchanges among hematological tumors

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• 作者：Joel LeMaoult (1) (2)
  Julien Caumartin (1) (2) (3)
  Marina Daouya (1) (2)
  Magdalena Switala (4)
  Vera Rebmann (4)
  Bertrand Arnulf (5)
  Edgardo D Carosella (1) (2)
  
  1. CEA ; Institute of Emerging Diseases and Innovative Therapies (iMETI) ; Research Division in Hematology and Immunology (SRHI) ; Saint-Louis Hospital ; Paris ; France
  2. University Paris Diderot ; Sorbonne Paris Cit茅 ; UMR E_5 Institut Universitaire d鈥橦ematologie ; Saint-Louis Hospital ; Paris ; France
  3. Biology and Biotechnology Ph.D. Program ; Univ Paris Diderot ; Sorbonne Paris Cite ; Paris ; France
  4. Institute for Transfusion Medicine ; University Hospital Essen ; Essen ; Germany
  5. D茅partement d鈥橧mmuno-H茅matologie ; H么pital Saint-Louis ; Paris ; France
  
• 关键词：Trogocytosis ; Leukemia ; HLA ; G ; Tumor escape ; Immune regulation
• 刊名：Journal of Hematology & Oncology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：8
• 期：1
• 全文大小：982 KB
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• 刊物主题：Oncology; Hematology; Cancer Research;
• 出版者：BioMed Central
• ISSN：1756-8722

文摘

Trogocytosis is the transfer of plasma membrane fragments and the molecules they contain between one donor and one acceptor/acquirer cell. Through trogocytosis, acceptor cells temporarily display and use cell-surface molecules they do not express themselves, but borrow from other cells. Here, we investigated whether liquid tumors possessed a trogocytic capability, if immune escape molecules could be acquired by tumor cells, transferred between cells of the same tumor, and if this could benefit the tumor as a whole. For this, we investigated trogocytosis in hematological cell lines and freshly isolated hematological tumor cells. We demonstrate that hematological tumor lines possess a trogocytic capability that allows them to capture membranes that contain the immune-inhibitory molecule HLA-G from allogeneic as well as from autologous sources. We further show that freshly isolated hematological tumor cells also possess these capabilities. This work reports for the first time the trogocytic capabilities of liquid tumor cells and introduces the notion of immune escape strategy sharing among tumor cells through trogocytosis of membrane-bound immune-inhibitory molecules.