“Causes of death in asthma, COPD and non-respiratory hospitalized patients: a multicentric study-

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• 作者：Jose Gregorio Soto-Campos (1)
  Vicente Plaza (2)
  Joan B Soriano (3)
  Carlos Cabrera-López (4)
  Carlos Almonacid-Sánchez (5)
  Rosa Vazquez-Oliva (6)
  Jose Serrano (7)
  Aitor Ballaz-Quincoces (8)
  Alicia Padilla-Galo (9)
  Vanessa Santos (10)
  
• 关键词：Asthma ; COPD ; Respiratory failure ; Mortality ; Cardiovascular diseases.
• 刊名：BMC Pulmonary Medicine
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：13
• 期：1
• 全文大小：193 KB
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  43. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2466/13/73/prepub
  
• 作者单位：Jose Gregorio Soto-Campos (1)
  Vicente Plaza (2)
  Joan B Soriano (3)
  Carlos Cabrera-López (4)
  Carlos Almonacid-Sánchez (5)
  Rosa Vazquez-Oliva (6)
  Jose Serrano (7)
  Aitor Ballaz-Quincoces (8)
  Alicia Padilla-Galo (9)
  Vanessa Santos (10)
  
  1. Unidad de Gestion Clínica de Neumología y Alergia, Hospital de Jerez, C/ Sevilla n° 42; 1° J. C.P, Cádiz, 11402, Spain
  2. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
  3. Programa de Epidemiología e Investigación Clínica, Fundación Caubet-CIMERA, Illes Balears, Spain
  4. Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
  5. Hospital de Guadalajara, Guadalajara, Spain
  6. Hospital Infanta Elena, Huelva, Spain
  7. Hospital Comarcal de Inca, Palma de Mallorca, Spain
  8. Hospital de Galdakao, Vizcaya, Spain
  9. Hospital Costa del Sol, Málaga, Spain
  10. Fundación para la Gestión de la Investigación Biomédica de Cádiz, Cádiz, Spain
  
• ISSN：1471-2466

文摘

Background There is limited information on the causes of death in asthma patients. To determine the causes of death in hospitalized asthmatic patients and to compare with those observed in COPD patients and non-respiratory individuals, with a particular interest in associations with previous cardiovascular disease. Methods Retrospective case–control study which analyzed the deaths of all hospitalized patients admitted for any reason during January, April, July and October of 2008 in 13 Spanish centers. Medical records of deceased patients were reviewed, and demographic and clinical data were collected. Results A total of 2,826 deaths (mean age 75?years, 56% men) were included in the analysis, of which 82 (2.9%) were of patients with asthma and 283 (10%) with COPD. The most common causes of death in asthma patients were cardiovascular diseases (29.3%), malignancies (20.7%) and infections (14.6%); in COPD patients they were malignancies (26.5%), acute respiratory failure (25.8%) and cardiovascular diseases (21.6%). Asthma, compared to COPD patients, died significantly less frequently from acute respiratory failure and lung cancer. A multivariate logistic regression analysis failed to associate asthma with cardiovascular deaths. Conclusions Cardiovascular disease is the most frequent cause of death among hospitalized asthma patients. The specific causes of death differ between asthma and COPD patients.