A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode

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• 作者：Mi-Hyun Ahn (1)
  Byung-Lae Park (2)
  Shin-Hwa Lee (1)
  Sung-Woo Park (1)
  Jong-Sook Park (1)
  Do-Jin Kim (1)
  An-Soo Jang (1)
  Jai-Soung Park (3)
  Hwa-Kyun Shin (4)
  Soo-Taek Uh (5)
  Yang-Ki Kim (5)
  Young Whan Kim (6)
  Sung Koo Han (6)
  Ki-Suck Jung (7)
  Kye Young Lee (8)
  Sung Hwan Jeong (9)
  Jeong Woong Park (9)
  Byoung Whui Choi (10)
  In Won Park (10)
  Man Pyo Chung (11)
  Hyoung Doo Shin (12) (2)
  Jin Woo Song (13)
  Dong Soon Kim (13)
  Choon-Sik Park (1)
  Young-Soo Shim (14) (6)
  
• 刊名：Respiratory Research
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：12
• 期：1
• 全文大小：278KB
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• 作者单位：Mi-Hyun Ahn (1)
  Byung-Lae Park (2)
  Shin-Hwa Lee (1)
  Sung-Woo Park (1)
  Jong-Sook Park (1)
  Do-Jin Kim (1)
  An-Soo Jang (1)
  Jai-Soung Park (3)
  Hwa-Kyun Shin (4)
  Soo-Taek Uh (5)
  Yang-Ki Kim (5)
  Young Whan Kim (6)
  Sung Koo Han (6)
  Ki-Suck Jung (7)
  Kye Young Lee (8)
  Sung Hwan Jeong (9)
  Jeong Woong Park (9)
  Byoung Whui Choi (10)
  In Won Park (10)
  Man Pyo Chung (11)
  Hyoung Doo Shin (12) (2)
  Jin Woo Song (13)
  Dong Soon Kim (13)
  Choon-Sik Park (1)
  Young-Soo Shim (14) (6)
  
  1. Div. of Allergy and Respiratory Medicine, Dept. of Internal Medicine, Soonchunhyang Univ. Bucheon Hospital, 1174, Jung-dong, Wonmi-gu, Bucheon, 420-020, Korea
  2. Dept. of Genetic Epidemiology, SNP-Genetics Inc., B-1407, WooLim Lion鈥檚 Valley, 371-28 Gasan-Dong, Geumcheon-Ku, Seoul, 153-803, Korea
  3. Div. of Radiology, Soonchunhyang Univ. Bucheon Hosp., 1174 Jung-Dong, Wonmi-Gu, Bucheon, Gyeonggi-Do, 420-020, Korea
  4. Div. of Thoracic and Cardiovascular Surgery, Soonchunhyang Univ. Bucheon Hosp., 1174 Jung-Dong, Wonmi-Gu, Bucheon, Gyeonggi-Do, 420-020, Korea
  5. Div. of Allergy and Respiratory Medicine, Soonchunhyang Univ. Seoul Hosp., 657-58 Hannam-dong, Yongsan-gu, Seoul, 140-743, Korea
  6. Dept. of Internal Medicine, Seoul National Univ. Hosp., 28 Yongon-dong, Seoul, Korea
  7. Dept. of Respiratory and Critical Care Medicine, Hallym Univ., Seoul, Korea
  8. Dept. of Internal Medicine, College of Medicine, Dankook Univ., Cheonan, Korea
  9. Div. of Pulmonary Medicine, Dept. of Internal Medicine, Gachon Medical School Gil Medical Center, Cheonan, Korea
  10. Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea
  11. Div. of Pulmonary and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan Univ. School of Medicine, Seoul, Korea
  12. Dept. of Life Science, Sogang Univ., Sinsu-dong, Mapo-gu, Seoul, 121-742, Korea
  13. Div. of Pulmonary and Critical Care Medicine, Asan Medical Center, Univ. of Ulsan, Asanbyungwon-gil, Songpa-gu, Seoul, 138-736, Korea
  14. Dept. of Medicine, Armed Force Capital Hospital, Bundang-gu, Seongnam-si, Kyonggi-do, Korea
  

文摘

Background Interleukin-8 (IL-8) is a potent chemo-attractant cytokine responsible for neutrophil infiltration in lungs with idiopathic pulmonary fibrosis (IPF). The IL-8 protein and mRNA expression are increased in the lung with IPF. We evaluated the effect of single nucleotide polymorphisms (SNPs) of the IL-8 gene on the risk of IPF. Methods One promoter (rs4073T>A) and two intronic SNPs (rs2227307T>G and rs2227306C>T) of the IL-8 genes were genotyped in 237 subjects with IPF and 456 normal controls. Logistic regression analysis was applied to evaluate the association of these SNPs with IPF. IL-8 in BAL fluids was measured using a quantitative sandwich enzyme immunoassay, and promoter activity was assessed using the luciferase reporter assay. Results The minor allele frequencies of rs4073T>A and rs2227307T>G were significantly lower in the 162 subjects with surgical biopsy-proven IPF and 75 subjects with clinical IPF compared with normal controls in the recessive model (OR = 0.46 and 0.48, p = 0.006 and 0.007, respectively). The IL-8 protein concentration in BAL fluids significantly increased in 24 subjects with IPF compared with 14 controls (p = 0.009). Nine IPF subjects homozygous for the rs4073 T>A common allele exhibited higher levels of the IL-8 protein compared with six subjects homozygous for the minor allele (p = 0.024). The luciferase activity of the rs4073T>A common allele was significantly higher than that of the rs4073T>A minor allele (p = 0.002). Conclusion The common allele of a promoter SNP, rs4073T>A, may increase susceptibility to the development of IPF via up-regulation of IL-8.