SOXC Genes and the Control of Skeletogenesis
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  • 作者：Véronique Lefebvre ; Pallavi Bhattaram
  • 关键词：Bone ; Cartilage ; Cell fate ; Progenitor/stem cell ; SOXC ; Transcription
  • 刊名：Current Osteoporosis Reports
  • 出版年：2016
  • 出版时间：February 2016
  • 年：2016
  • 卷：14
  • 期：1
  • 页码：32-38
  • 全文大小：292 KB
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  • 作者单位：Véronique Lefebvre (1)
    Pallavi Bhattaram (1)

    1. Department of Cellular & Molecular Medicine, Orthopaedic and Rheumatologic Research Center, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
  • 刊物主题：Orthopedics; Epidemiology;
  • 出版者：Springer US
  • ISSN：1544-2241
    • 文摘
    The SOXC group of transcription factors, composed of SOX4, SOX11, and SOX12, has evolved to fulfill key functions in cell fate determination. Expressed in many types of progenitor/stem cells, including skeletal progenitors, SOXC proteins potentiate pathways critical for cell survival and differentiation. As skeletogenesis unfolds, SOXC proteins ensure cartilage primordia delineation by amplifying canonical WNT signaling and antagonizing the chondrogenic action of SOX9 in perichondrium and presumptive articular joint cells. They then ensure skeletal elongation by inducing growth plate formation via enabling non-canonical WNT signaling. Human studies have associated SOX4 with bone mineral density and fracture risk in osteoporotic patients, and SOX11 with Coffin-Siris, a syndrome that includes skeletal dysmorphism. Meanwhile, in vitro and mouse studies have suggested important cell-autonomous roles for SOXC proteins in osteoblastogenesis. We here review current knowledge and gaps in understanding of SOXC protein functions, with an emphasis on the skeleton and possible links to osteoporosis.

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