Heterogeneous pattern of DNA methylation in developmentally important genes correlates with its chromatin conformation
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- 作者：Puja Sinha ; Kiran Singh ; Manisha Sachan
- 关键词：DNA methylation ; Chromatin conformation ; Chromatin ; immunoprecipitation (ChIP) ; Sox11 ; C ; mos ; HoxB5 ; Tissue ; specific gene expression
- 刊名：BMC Molecular Biology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：3095KB
- 刊物主题：Biochemistry, general; Nucleic Acid Chemistry; Cell Biology;
- 出版者：BioMed Central
- ISSN：1471-2199
- 卷排序：18
文摘
BackgroundDNA methylation is a major epigenetic modification, playing a crucial role in the development and differentiation of higher organisms. DNA methylation is also known to regulate transcription by gene repression. Various developmental genes such as c-mos, HoxB5, Sox11, and Sry show tissue-specific gene expression that was shown to be regulated by promoter DNA methylation. The aim of the present study is to investigate the establishment of chromatin marks (active or repressive) in relation to heterogeneous methylation in the promoter regions of these developmentally important genes.