SOX5 promotes epithelial–mesenchymal transition and cell invasion via regulation of Twist1 in hepatocellular carcinoma
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- 作者：Dong Wang ; Sheng Han ; Xing Wang ; Rui Peng ; Xiangcheng Li
- 关键词：SOX5 ; HCC ; EMT ; Twist1
- 刊名：Medical Oncology
- 出版年：2015
- 出版时间：February 2015
- 年：2015
- 卷：32
- 期：2
- 全文大小：4,912 KB
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18. Jia X, Li X, Xu - 刊物主题：Oncology; Hematology; Pathology; Internal Medicine;
- 出版者：Springer US
- ISSN：1559-131X
文摘
The transcription factor sex determining region Y-box protein 5 (SOX5) plays important roles in various types of cancers. However, the expression and function of SOX5 in hepatocellular carcinoma (HCC) have not been elucidated. Here, we found that SOX5 is significantly up-regulated in HCC tissues and cell lines. Gain- and loss-of-function studies demonstrated that SOX5 promoted HCC cell migration and invasion. In addition, we revealed that SOX5 is linked to epithelial–mesenchymal transition (EMT) by regulation of Twist1. Our results indicate for the first time that SOX5 is a novel regulator of EMT in HCC and may be a potential therapeutic target for HCC metastasis.