Natalizumab treatment reduces L-selectin (CD62L) in CD4+ T cells

详细信息    查看全文

• 作者：Michela Spadaro ; Marzia Caldano ; Fabiana Marnetto…
• 关键词：CD62L ; Natalizumab ; PML ; Multiple sclerosis ; IRIS
• 刊名：Journal of Neuroinflammation
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：12
• 期：1
• 全文大小：1,632 KB
• 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
• 出版者：BioMed Central
• ISSN：1742-2094

文摘

Background The purpose of this research was to validate the low expression of L-selectin (CD62L) in natalizumab (NTZ)-treated patients. CD62L is involved in rolling and transmigration of leukocyte cells. A correlation between CD62LCD4+ T cells low expression and progressive multifocal leukoencephalopathy (PML) development has been suggested in multiple sclerosis (MS) patients treated with NTZ.