31P magnetic resonance spectroscopy of the breast and the influence of the menstrual cycle
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- 作者：B. L. Stehouwer (1)
W. J. M. van der Kemp (1)
P. R. Luijten (1)
M. A. A. J. van den Bosch (1)
W. B. Veldhuis (1)
J. P. Wijnen (1)
D. W. J. Klomp (1) - 关键词：31P MRS ; Breast ; Menstrual cycle ; Glandular tissue
- 刊名：Breast Cancer Research and Treatment
- 出版年：2014
- 出版时间：April 2014
- 年：2014
- 卷：144
- 期：3
- 页码：583-589
- 全文大小：757 KB
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W. J. M. van der Kemp (1)
P. R. Luijten (1)
M. A. A. J. van den Bosch (1)
W. B. Veldhuis (1)
J. P. Wijnen (1)
D. W. J. Klomp (1)
1. Department of Radiology, University Medical Center Utrecht, Room E01.132, PO Box 85500, 3508 GA, Utrecht, Netherlands - ISSN：1573-7217
文摘
Phosphorus metabolite ratios are potential biomarkers in breast cancer diagnosis and treatment monitoring. Our purpose was to investigate the metabolite ratios phosphomonoester to phosphodiester, phosphoethanolamine (PE) to glycerophosphoethanolamine (GPE), and phosphocholine (PC) to glycerophosphocholine (GPC) in glandular breast tissue, and the potential effect of the menstrual cycle, using 31P magnetic resonance spectroscopy (MRS) at 7T. Seven women with regular menstrual cycles each underwent four examinations using a 3D 31P multi-echo magnetic resonance spectroscopic imaging sequence. Peak integrals were assessed using IDL and JMRUI software. First, T2 relaxation times were calculated using multi-echo data pooled across subjects and time points. Subsequent, metabolite ratios were calculated for each phase of the menstrual cycle using the calculated T2 values to account for when combining the free induction decay and all five echoes. The metabolite ratios were calculated both on group level and individually. T2 decay fits resulted in a T2 relaxation time for PE of 154?ms (95?% CI 144-64), for PC of 173?ms (95?% CI 148-05), for Pi of 188?ms (95?% CI 182-93), for GPE of 48?ms (95?% CI 44-3), and for GPC of 23?ms (95?% CI 21-6). The metabolite ratios analyzed on group level showed negligible variation throughout the menstrual cycle. Individual results did show an apparent intra-individual variation; however, not significant due to the measurements-uncertainty. To conclude, phospholipids in glandular tissue as measured with 31P MRS at 7?T are not significantly affected by the menstrual cycle.