Phosphatidylcholine contributes to in vivo 31P MRS signal from the human liver
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- 作者：Marek Chmelík ; Ladislav Valkovi? ; Peter Wolf ; Wolfgang Bogner…
- 关键词：Liver ; Phosphatidylcholine ; Gallbladder ; In vivo 31P magnetic resonance spectroscopy ; 7 Tesla
- 刊名：European Radiology
- 出版年：2015
- 出版时间：July 2015
- 年：2015
- 卷：25
- 期：7
- 页码：2059-2066
- 全文大小：769 KB
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25.Bell JD, Cox IJ, Sargentoni J et al (1993) A 31P and 1H-NMR investigation in vitro of normal and abnormal hum - 作者单位：Marek Chmelík (1)
Ladislav Valkovi? (1) (2)
Peter Wolf (3)
Wolfgang Bogner (1)
Martin Gajdo?ík (1)
Emina Halilbasic (4)
Stephan Gruber (1)
Michael Trauner (4)
Michael Krebs (3)
Siegfried Trattnig (1)
Martin Kr??ák (1) (3)
1. MR Centre of Excellence, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
2. Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia
3. Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
4. Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Imaging and Radiology
Diagnostic Radiology
Interventional Radiology
Neuroradiology
Ultrasound
Internal Medicine - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-1084
文摘
Objectives To demonstrate the overlap of the hepatic and bile phosphorus (31P) magnetic resonance (MR) spectra and provide evidence of phosphatidylcholine (PtdC) contribution to the in vivo hepatic 31P MRS phosphodiester (PDE) signal, suggested in previous reports to be phosphoenolpyruvate (PEP). Methods Phantom measurements to assess the chemical shifts of PEP and PtdC signals were performed at 7?T. A retrospective analysis of hepatic 3D 31P MR spectroscopic imaging (MRSI) data from 18 and five volunteers at 3?T and 7?T, respectively, was performed. Axial images were inspected for the presence of gallbladder, and PDE signals in representative spectra were quantified. Results Phantom experiments demonstrated the strong pH-dependence of the PEP chemical shift and proved the overlap of PtdC and PEP (~2?ppm relative to phosphocreatine) at hepatic pH. Gallbladder was covered in seven of 23 in vivo 3D-MRSI datasets. The PDE gall/γ-ATPliver ratio was 4.8-fold higher (p--.001) in the gallbladder (PDEgall/γ-ATPliver--.61?±-.79) than in the liver (PDEliver/γ-ATPliver--.75?±-.15). In vivo 7?T 31P MRSI allowed good separation of PDE components. The gallbladder is a strong source of contamination in adjacent 31P MR hepatic spectra due to biliary phosphatidylcholine. Conclusions In vivo 31P MR hepatic signal at 2.06?ppm may represent both phosphatidylcholine and phosphoenolpyruvate, with a higher phosphatidylcholine contribution due to its higher concentration. Key Points -In vivo 31 P MRS from the gallbladder shows a dominant biliary phosphatidylcholine signal at 2.06?ppm. -Intrahepatic 31 P MRS signal at 2.06?ppm may represent both intrahepatic phosphatidylcholine and phosphoenolpyruvate. -In vivo 31 P MRS has the potential to monitor hepatic phosphatidylcholine.