The dehydration dynamics of a model cell membrane induced by cholesterol analogue 6-ketocholestanol investigated using sum frequency generation vibrational spectroscopy
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- 作者：Sulan Ma ; Kangzhen Tian ; Shuji Ye
- 关键词：membrane dehydration ; sum frequency generation ; membrane ; bound water ; membrane dipole potential ; Hofmeister effect
- 刊名：SCIENCE CHINA Chemistry
- 出版年：2015
- 出版时间：July 2015
- 年：2015
- 卷：58
- 期：7
- 页码：1176-1186
- 全文大小：1,245 KB
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26.Li HC, Ye SJ, Wei F, Ma SL, Luo Y. In situ molecular-level insights into the interfacial structu - 作者单位：Sulan Ma (1)
Kangzhen Tian (1) (2)
Shuji Ye (1) (2)
1. Hefei National Laboratory for Physical Sciences at the Microscale; Department of Chemical Physics, University of Science and Technology of China, Hefei, 230026, China
2. Synergetic Innovation Center of Quantum Information & Quantum Physics, University of Science and Technology of China, Hefei, 230026, China - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Chinese Library of Science
Chemistry - 出版者：Science China Press, co-published with Springer
- ISSN：1869-1870
文摘
Dehydration of a surface is the first step for the interaction between biomolecules and the surface. In this study, we systematically investigated the influence of cholesterol analog 6-ketocholestanol (6-KC) on the dehydration of model cell membrane, using sum frequency generation vibrational spectroscopy. In pure DI water environment, two separate dehydration dynamic components were observed in neutrally charged and isotopically labeled 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and positively charged 1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine(chloride salt) (DMEPC) bilayer: a large-amplitude fast component and a small-amplitude slow component, which originated from the water molecules with a weak and a strong water-membrane bound strengths, respectively. Dehydration of a negatively charged mixed DMPC/DMPG bilayer lead to the membrane-bound water being reorganized to ordered structures quickly. It is evident that the water-membrane bound strengths depend largely on the charge status of the lipid and has an order of neutrally charged membrane?positively charged membrane?negatively charged membrane. In an ionic environment, KCl solution can not only dehydrate DMPC bilayer, but also prevent the 6-KC from further dehydrating this model cell membrane. We observed that the dehydration dynamics behavior of DMPC bilayer in the presence of the chaotropic anions is similar to that of the negatively charged DMPG bilayer because of the penetration of chaotropic anions into the DMPC bilayer. The degree of dehydration difficulty in kosmotropic anions follows a Hofmeister series and linearly correlates with the hydration Gibbs free energy of the anions. Our results provide a molecular basis for the interpretation of the Hofmeister effect of kosmotropic anions on ion transport proteins.