Iron and copper in male reproduction: a double-edged sword
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- 作者：Eva Tvrda (1) (2)
Rohan Peer (1)
Suresh C. Sikka (3)
Ashok Agarwal (1)
1. Center for Reproductive Medicine ; Cleveland Clinic ; Cleveland ; OH ; USA
2. Department of Animal Physiology ; Slovak University of Agriculture ; Nitra ; Slovakia
3. Department of Urology ; Tulane University School of Medicine ; New Orleans ; LA ; USA - 关键词：Iron ; Copper ; Male fertility ; Spermatozoa ; Oxidative stress ; ROS
- 刊名：Journal of Assisted Reproduction and Genetics
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：32
- 期：1
- 页码：3-16
- 全文大小：3,531 KB
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- 刊物主题：Medicine & Public Health
Gynecology
Developmental Biology
Human Genetics - 出版者：Springer Netherlands
- ISSN：1573-7330
文摘
Iron and copper are essential trace nutrients playing important roles in general health and fertility. However, both elements are highly toxic when accumulating in large quantities. Their direct or indirect impact on the structure and function of male gonads and gametes is not completely understood yet. Excess or deficiency of either element may lead to defective spermatogenesis, reduced libido, and oxidative damage to the testicular tissue and spermatozoa, ultimately leading to fertility impairment. This review will detail the complex information currently available on the dual roles iron and copper play in male reproduction.