Altered sphingoid base profiles in type 1 compared to type 2 diabetes

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• 作者：Nancy Wei ; Jessica Pan ; Rodica Pop-Busui ; Alaa Othman…
• 关键词：Atypical sphingolipids ; Biomarker ; Deoxysphingolipids ; Metabolic syndrome ; Type 2 diabetes mellitus ; Type 1 diabetes mellitus
• 刊名：Lipids in Health and Disease
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：13
• 期：1
• 全文大小：222 KB
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• 刊物主题：Lipidology; Medical Biochemistry;
• 出版者：BioMed Central
• ISSN：1476-511X

文摘

Background Sphingolipids are increasingly recognized to play a role in insulin resistance and diabetes. Recently we reported significant elevations of 1-deoxysphingolipids (1-deoxySL) - an atypical class of sphingolipids in patients with metabolic syndrome (MetS) and diabetes type 2 (T2DM). It is unknown whether 1-deoxySL in patients with diabetes type 1 (T1DM) are similarly elevated. Findings We analyzed the long chain base profile by LC-MS after hydrolyzing the N-acyl and O-linked headgroups in plasma from individuals with T1DM (N--7), T2DM (N--0) and healthy controls (N--3). 1-deoxySLs were significantly higher in the groups with T2DM but not different between T1DM and controls. In contrast to patients with T2DM, 1-deoxSL levels are not elevated in T1DM. Conclusions Our study indicates that the 1-deoxySL formation is not per-se caused by hyperglycemia but rather specifically associated with metabolic changes in T2DM, such as elevated triglyceride levels.