The role of epidermal sphingolipids in dermatologic diseases

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• 作者：Sonia Borodzicz ; Lidia Rudnicka ; Dagmara Mirowska-Guzel…
• 关键词：Sphingolipids ; Ceramide ; Sphingosine ; 1 ; phosphate ; Dermatologic diseases ; Psoriasis ; Atopic dermatitis ; Ichthyosis
• 刊名：Lipids in Health and Disease
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：15
• 期：1
• 全文大小：563 KB
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• 作者单位：Sonia Borodzicz (1)
  Lidia Rudnicka (2)
  Dagmara Mirowska-Guzel (3)
  Agnieszka Cudnoch-Jedrzejewska (1)
  
  1. Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1B, 02-097, Warsaw, Poland
  2. Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008, Warsaw, Poland
  3. Department of Experimental and Clinical Pharmacology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1B, 02-097, Warsaw, Poland
  
• 刊物主题：Lipidology; Medical Biochemistry;
• 出版者：BioMed Central
• ISSN：1476-511X

文摘

Sphingolipids, a group of lipids containing the sphingoid base, have both structural and biological functions in human epidermis. Ceramides, as a part of extracellular lipids in the stratum corneum, are important elements of the skin barrier and are involved in the prevention of transepidermal water loss. In addition, ceramides regulate such processes as proliferation, differentiation and apoptosis of keratinocytes. Another important sphingolipid, sphingosine-1-phosphate (S1P), inhibits proliferation and induces differentiation of keratinocytes. A recent clinical study of the efficacy and safety of ponesimod (a selective modulator of the S1P receptor 1) suggested that sphingolipid metabolism may become a new target for the pharmacological treatment of psoriasis. The role of sphingolipids in some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses was summarized in this article. Keywords Sphingolipids Ceramide Sphingosine-1-phosphate Dermatologic diseases Psoriasis Atopic dermatitis Ichthyosis