Upregulation of S1P1 and Rac1 receptors in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia
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- 作者：Julia Zimmer ; Toshiaki Takahashi ; Johannes W. Duess…
- 关键词：Congenital diaphragmatic hernia ; Pulmonary hypertension ; Nitrofen ; Sphingosine kinase ; Sphingosine ; 1 ; phosphate ; Rac1
- 刊名：Pediatric Surgery International
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：32
- 期：2
- 页码：147-154
- 全文大小：3,303 KB
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Toshiaki Takahashi (1)
Johannes W. Duess (1) (2)
Alejandro D. Hofmann (1) (3)
Prem Puri (1) (2)
1. National Children’s Research Centre, Our Lady’s Children’s Hospital, Crumlin, Dublin, Ireland
2. School of Medicine and Medical Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
3. Department of Pediatric Surgery, Hannover Medical School, Hannover, Germany - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Pediatrics
Surgery
Pediatric Surgery - 出版者：Springer Berlin / Heidelberg
- ISSN：1437-9813
文摘
Purpose Sphingolipids play a crucial role in pulmonary development. The sphingosine kinase 1 (SphK1) modulates the synthesis of sphingolipid sphingosine-1-phosphate (S1P). S1P regulates cell proliferation and angiogenesis via different receptors, S1P1, S1P2 and S1P3, which all influence the expression of Ras-related C3 botulinum toxin substrate 1 (Rac1). We designed this study to test the hypothesis that the S1P/Rac1 pathway is altered in the nitrofen-induced CDH model.