Bacterial colonization of VEPTR implants under repeated expansions in children with severe early onset spinal deformities

详细信息    查看全文

• 作者：Christian Plaass ; Carol Claudius Hasler ; Ulrich Heininger…
• 关键词：Sonication ; Vertical expandable prosthetic rib ; Growth ; retaining implants ; Surgical site infection ; Colonization
• 刊名：European Spine Journal
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：25
• 期：2
• 页码：549-556
• 全文大小：510 KB
• 参考文献：1.Campbell RM, Smith MD, Mayes TC et al (2003) The characteristics of thoracic insufficiency syndrome associated with fused ribs and congenital scoliosis. J Bone Joint Surg Am 85-A:399–408PubMed
  2.Dubousset J, Herring JA, Shufflebarger H (1989) The crankshaft phenomenon. J Pediatr Orthop 9:541–550PubMed CrossRef
  3.Motoyama EK, Deeney VF, Fine GF et al (2006) Effects on lung function of multiple expansion thoracoplasty in children with thoracic insufficiency syndrome: a longitudinal study. Spine 31:284–290. doi:10.​1097/​01.​brs.​0000197203.​76653.​d0 PubMed CrossRef
  4.Mammano S, Scapinelli R (1992) Plaster casts for the correction of idiopathic scoliosis. Acta Orthop Belg 58(Suppl 1):81–84PubMed
  5.Thompson GH, Lenke LG, Akbarnia BA et al (2007) Early onset scoliosis: future directions. J Bone Joint Surg Am 89:163–166. doi:10.​2106/​JBJS.​F.​01513 PubMed CrossRef
  6.Thompson GH, Akbarnia BA, Kostial P et al (2005) Comparison of single and dual growing rod techniques followed through definitive surgery: a preliminary study. Spine 30:2039–2044PubMed CrossRef
  7.Akel I, Yazici M (2009) Growth modulation in the management of growing spine deformities. J Child Orthop 3:1–9. doi:10.​1007/​s11832-008-0145-6 PubMed PubMedCentral CrossRef
  8.Eberle CF (1988) Failure of fixation after segmental spinal instrumentation without arthrodesis in the management of paralytic scoliosis. J Bone Joint Surg Am 70:696–703PubMed
  9.Hasler C-C, Mehrkens A, Hefti F (2010) Efficacy and safety of VEPTR instrumentation for progressive spine deformities in young children without rib fusions. Eur Spine J 19:400–408. doi:10.​1007/​s00586-009-1253-9 PubMed PubMedCentral CrossRef
  10.Campbell RM, Smith MD, Mayes TC et al (2004) The effect of opening wedge thoracostomy on thoracic insufficiency syndrome associated with fused ribs and congenital scoliosis. J Bone Joint Surg Am 86-A:1659–1674PubMed
  11.Campbell RM, Smith MD, Hell-Vocke AK (2004) Expansion thoracoplasty: the surgical technique of opening-wedge thoracostomy. Surgical technique. J Bone Joint Surg Am 86-A(Suppl 1):51–64PubMed
  12.Emans JB, Caubet JF, Ordonez CL et al (2005) The treatment of spine and chest wall deformities with fused ribs by expansion thoracostomy and insertion of vertical expandable prosthetic titanium rib: growth of thoracic spine and improvement of lung volumes. Spine 30:S58–S68PubMed CrossRef
  13.Hell AK, Campbell RM, Hefti F (2005) The vertical expandable prosthetic titanium rib implant for the treatment of thoracic insufficiency syndrome associated with congenital and neuromuscular scoliosis in young children. J Pediatr Orthop B 14:287–293PubMed CrossRef
  14.Ramirez N, Flynn JM, Emans JB et al (2010) Vertical expandable prosthetic titanium rib as treatment of thoracic insufficiency syndrome in spondylocostal dysplasia. J Pediatr Orthop 30:521–526. doi:10.​1097/​BPO.​0b013e3181e78e6c​ PubMed CrossRef
  15.Skaggs DL, Sankar WN, Albrektson J et al (2009) Weight gain following vertical expandable prosthetic titanium ribs surgery in children with thoracic insufficiency syndrome. Spine 34:2530–2533. doi:10.​1097/​BRS.​0b013e3181bd09f5​ PubMed CrossRef
  16.Caubet J-F, Emans JB, Smith JT et al (2009) Increased hemoglobin levels in patients with early onset scoliosis: prevalence and effect of a treatment with Vertical Expandable Prosthetic Titanium Rib (VEPTR). Spine 34:2534–2536. doi:10.​1097/​BRS.​0b013e3181bd0fc4​ PubMed CrossRef
  17.Akbarnia BA, Emans JB (2010) Complications of growth-sparing surgery in early onset scoliosis. Spine 35:2193–2204. doi:10.​1097/​BRS.​0b013e3181f070b5​ PubMed CrossRef
  18.Smith JT, Smith MS (2011) Can infection associated with rib distraction techniques be managed without implant removal? Spine 36:2176–2179. doi:10.​1097/​BRS.​0b013e3182045abc​ PubMed CrossRef
  19.Mason PK, Dimarco JP, Ferguson JD et al (2010) Sonication of explanted cardiac rhythm management devices for the diagnosis of pocket infections and asymptomatic bacterial colonization. Pacing Clin Electrophysiol. doi:10.​1111/​j.​1540-8159.​2010.​02820.​x PubMed
  20.Rieger UM, Pierer G, Lüscher NJ, Trampuz A (2009) Sonication of removed breast implants for improved detection of subclinical infection. Aesthetic Plast Surg 33:404–408. doi:10.​1007/​s00266-009-9333-0 PubMed CrossRef
  21.Trampuz A, Piper KE, Jacobson MJ et al (2007) Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med 357:654–663. doi:10.​1056/​NEJMoa061588 PubMed CrossRef
  22.Sampedro MF, Huddleston PM, Piper KE et al (2010) A biofilm approach to detect bacteria on removed spinal implants. Spine 35:1218–1224. doi:10.​1097/​BRS.​0b013e3181c3b2f3​ PubMed
  23.Bonkat G, Rieken M, Rentsch CA et al (2010) Improved detection of microbial ureteral stent colonisation by sonication. World J Urol. doi:10.​1007/​s00345-010-0535-5
  24.Piper KE, Jacobson MJ, Cofield RH et al (2009) Microbiologic diagnosis of prosthetic shoulder infection by use of implant sonication. J Clin Microbiol 47:1878–1884. doi:10.​1128/​JCM.​01686-08 PubMed PubMedCentral CrossRef
  25.Rohacek M, Weisser M, Kobza R et al (2010) Bacterial colonization and infection of electrophysiological cardiac devices detected with sonication and swab culture. Circulation 121:1691–1697. doi:10.​1161/​CIRCULATIONAHA.​109.​906461 PubMed CrossRef
  26.Horan TC, Gaynes RP, Martone W et al (1992) CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Am J Infect Control 20:271–274. doi:10.​1016/​S0196-6553(05)80201-9 PubMed CrossRef
  27.Trampuz A, Piper KE, Hanssen AD et al (2006) Sonication of explanted prosthetic components in bags for diagnosis of prosthetic joint infection is associated with risk of contamination. J Clin Microbiol 44:628–631. doi:10.​1128/​JCM.​44.​2.​628-631.​2006 PubMed PubMedCentral CrossRef
  28.Fang A, Hu SS, Endres N, Bradford DS (2005) Risk factors for infection after spinal surgery. Spine 30:1460–1465PubMed CrossRef
  29.Reinker K, Simmons JW, Patil V, Stinson Z (2011) Can VEPTR(®) control progression of early-onset kyphoscoliosis? A cohort study of VEPTR(®) patients with severe kyphoscoliosis. Clin Orthop Relat Res 469:1342–1348. doi:10.​1007/​s11999-010-1697-6 PubMed PubMedCentral CrossRef
  30.Esteban J, Sandoval E, Cordero-Ampuero J et al (2012) Sonication of intramedullary nails: clinically-related infection and contamination. Open Orthop J 6:255–260. doi:10.​2174/​1874325001206010​255 PubMed PubMedCentral CrossRef
  31.Collins I, Wilson-Macdonald J, Chami G et al (2008) The diagnosis and management of infection following instrumented spinal fusion. Eur Spine J 17:445–450. doi:10.​1007/​s00586-007-0559-8 PubMed PubMedCentral CrossRef
  32.Mackenzie WGS, Matsumoto H, Williams BA et al (2013) Surgical site infection following spinal instrumentation for scoliosis: a multicenter analysis of rates, risk factors, and pathogens. J Bone Joint Surg Am 95:800–806. doi:10.​2106/​JBJS.​L.​00010 S1–2 PubMed CrossRef
  33.Ramage G, Tunney MM, Patrick S et al (2003) Formation of Propionibacterium acnes biofilms on orthopaedic biomaterials and their susceptibility to antimicrobials. Biomaterials 24:3221–3227PubMed CrossRef
  34.Holmberg A, Lood R, Mörgelin M et al (2009) Biofilm formation by Propionibacterium acnes is a characteristic of invasive isolates. Clin Microbiol Infect 15:787–795. doi:10.​1111/​j.​1469-0691.​2009.​02747.​x PubMed CrossRef
  35.Vandecasteele SJ, Van Wijngaerden E, Van Eldere J, Peetermans WE (2000) New insights in the pathogenesis of foreign body infections with coagulase negative staphylococci. Acta Clin Belg 55:148–153PubMed
  36.Karau MJ, Greenwood-Quaintance KE, Schmidt SM et al (2013) Microbial biofilms and breast tissue expanders. Biomed Res Int 2013:254940. doi:10.​1155/​2013/​254940 PubMed PubMedCentral CrossRef
  37.Nandyala SV, Schwend RM (2013) Prevalence of intraoperative tissue bacterial contamination in posterior pediatric spinal deformity surgery. Spine 38:E482–E486. doi:10.​1097/​BRS.​0b013e3182893be1​ PubMed CrossRef
  38.Bess S, Akbarnia BA, Thompson GH et al (2010) Complications of growing-rod treatment for early-onset scoliosis: analysis of one hundred and forty patients. J Bone Joint Surg Am 92:2533–2543. doi:10.​2106/​JBJS.​I.​01471 PubMed CrossRef
  39.Trampuz A, Zimmerli W (2006) Diagnosis and treatment of infections associated with fracture-fixation devices. Injury 37(Suppl 2):S59–S66. doi:10.​1016/​j.​injury.​2006.​04.​010 PubMed CrossRef
  40.Goodman SB, Yao Z, Keeney M, Yang F (2013) The future of biologic coatings for orthopaedic implants. Biomaterials 34:3174–3183. doi:10.​1016/​j.​biomaterials.​2013.​01.​074 PubMed PubMedCentral CrossRef
  41.Cheung KM-C, Cheung JP-Y, Samartzis D et al (2012) Magnetically controlled growing rods for severe spinal curvature in young children: a prospective case series. Lancet. doi:10.​1016/​S0140-6736(12)60112-3
  42.Akbarnia BA, Mundis GM, Salari P et al (2012) Innovation in growing rod technique: a study of safety and efficacy of a magnetically controlled growing rod in a porcine model. Spine 37:1109–1114. doi:10.​1097/​BRS.​0b013e318240ff67​ PubMed CrossRef
  43.Dannawi Z, Altaf F, Harshavardhana NS et al (2013) Early results of a remotely-operated magnetic growth rod in early-onset scoliosis. Bone Joint J 95-B:75–80. doi:10.​1302/​0301-620X.​95B1.​29565 PubMed CrossRef
  44.Akbarnia BA, Cheung K, Noordeen H et al (2013) Next generation of growth-sparing techniques: preliminary clinical results of a magnetically controlled growing rod in 14 patients with early-onset scoliosis. Spine 38:665–670. doi:10.​1097/​BRS.​0b013e3182773560​ PubMed CrossRef
  45.Puig-Verdié L, Alentorn-Geli E, González-Cuevas A et al (2013) Implant sonication increases the diagnostic accuracy of infection in patients with delayed, but not early, orthopaedic implant failure. Bone Joint J 95-B:244–249. doi:10.​1302/​0301-620X.​95B2.​30486 PubMed CrossRef
  46.Pandey R, Berendt AR, Athanasou NA (2000) Histological and microbiological findings in non-infected and infected revision arthroplasty tissues. Arch Orthop Trauma Surg 120:570–574. doi:10.​1007/​s004020000174 PubMed CrossRef
  47.Widmer AF (2001) New Developments in Diagnosis and Treatment of Infection in Orthopedic Implants. Clin Infect Dis 33:S94–S106. doi:10.​1086/​321863 PubMed CrossRef
  
• 作者单位：Christian Plaass (1) (3)
  Carol Claudius Hasler (1)
  Ulrich Heininger (2)
  Daniel Studer (1)
  
  1. Orthopaedic Department, University Children’s Hospital Basel, Spitalstrasse 33, 4056, Basel, Switzerland
  3. Orthopaedic Department, Hannover Medical School, Anna-von-Borries Strasse 1-7, 30625, Hannover, Germany
  2. Division of Pediatric Infectious Diseases, University Children’s Hospital Basel, Spitalstrasse 33, Basel, 4056, Switzerland
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgical Orthopedics
  Neurosurgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0932

文摘

Purpose Historically, severe spinal and thoracic deformities in children were treated with early long spinal fusions. This prevented further growth of the spine and thorax and often led to small stiff thoraces. Therefore, growth-retaining implants, like vertical expandable titanium ribs (VEPTR), were developed to stimulate thoracic and spinal growth. To accommodate growth, these implants have to be expanded every 6 months. Infection rates of up to 2 % per procedure are reported. Exchange of implant parts allows analyzing the development of implant-related infections and subclinical colonizations.