NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase
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- 作者：Zhimin Gu ; Jiliang Xia ; Hongwei Xu ; Ivana Frech…
- 关键词：NEK2 ; Pyruvate kinase ; Multiple myeloma ; Alternative splicing
- 刊名：Journal of Hematology & Oncology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：10
- 期：1
- 全文大小：2121KB
- 刊物主题：Oncology; Hematology; Cancer Research;
- 出版者：BioMed Central
- ISSN：1756-8722
- 卷排序：10
文摘
BackgroundAerobic glycolysis, a hallmark of cancer, is characterized by increased metabolism of glucose and production of lactate in normaxia. Recently, pyruvate kinase M2 (PKM2) has been identified as a key player for regulating aerobic glycolysis and promoting tumor cell proliferation and survival.