Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population
详细信息 查看全文
- 作者：Chaymaa Marouf ; Stella Göhler ; Miguel Inacio Da Silva Filho ; Omar Hajji…
- 关键词：Breast cancer ; Driver genes ; APOBEC3 ; Genetic susceptibility ; Single nucleotide polymorphism
- 刊名：BMC Cancer
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：16
- 期：1
- 全文大小：492 KB
- 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2407
文摘
Background Breast cancer (BC) is the most prevalent cancer in women and a major public health problem in Morocco. Several Moroccan studies have focused on studying this disease, but more are needed, especially at the genetic and molecular levels. Therefore, we investigated the potential association of several functional germline variants in the genes commonly mutated in sporadic breast cancer.