Dissimilarity between sporadic, non-BRCA1/2 families and hereditary breast cancer, linked to BRCA genes, in the Tunisian population

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• 作者：Aouatef Riahi ; Mohamel el Gourabi ; Habiba Chabouni-bouhamed
• 关键词：Breast cancer ; BRCA1/BRCA2 ; Classification ; Psychosocial factors
• 刊名：Breast Cancer
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：23
• 期：5
• 页码：807-812
• 全文大小：570 KB
• 刊物主题：Surgical Oncology; Oncology; Surgery; Cancer Research;
• 出版者：Springer Japan
• ISSN：1880-4233
• 卷排序：23

文摘

BackgroundMost breast cancers (90 %) are sporadic. Only 5–10 % of all cancer cases can be attributed to genetic defects. BRCA genes are strongly incriminated in the hereditary predisposition to the disease. The purpose of our study was to provide more efficient approach to identify pathogenic BRCA mutation carriers and to determine subgroups within the non-BRCA tumor class.