Whole Transcriptome Analysis of Pre-invasive and Invasive Early Squamous Lung Carcinoma in Archival Laser Microdissected Samples
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- 作者：Andre Koper ; Leo A. H. Zeef ; Leena Joseph ; Keith Kerr ; John Gosney…
- 关键词：Preinvasive squamous cell cancer ; Invasive squamous cell cancer ; Exon arrays ; Gene expression profiling ; Microdissection
- 刊名：Respiratory Research
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：3940KB
- 刊物主题：Pneumology/Respiratory System;
- 出版者：BioMed Central
- ISSN：1465-993X
- 卷排序：18
文摘
BackgroundPreinvasive squamous cell cancer (PSCC) are local transformations of bronchial epithelia that are frequently observed in current or former smokers. Their different grades and sizes suggest a continuum of dysplastic change with increasing severity, which may culminate in invasive squamous cell carcinoma (ISCC). As a consequence of the difficulty in isolating cancerous cells from biopsies, the molecular pathology that underlies their histological variability remains largely unknown.