Interaction of LDL and platelets in ischaemic and ischaemic risk subjects
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- 作者：Yashika Gupta (1)
V. Mallika (2)
D. K. Srivastava (2) - 关键词：LDL ; ox ; LDL ; Calcium ; Platelet ; Platelet aggregation
- 刊名：Indian Journal of Clinical Biochemistry
- 出版年：2005
- 出版时间：January 2005
- 年：2005
- 卷：20
- 期：1
- 页码：87-94
- 全文大小：857KB
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10. Block, L.H., Knorr, M., Vogt, E., Locher, R., Vetter, - 作者单位：Yashika Gupta (1)
V. Mallika (2)
D. K. Srivastava (2)
1. 5721 San Diego Street, 94530, El Cerrito, CA, USA
2. Department of Biochemistry, G.B. Pant Hospital, 110002, New Delhi, India
文摘
Platelets play a vital role in the progression of atherosclerosis and thrombosis, a major cause of death worldwide. Platelets are activated by many triggers like elevated LDL in blood resulting in aggregation and formation of plaque. The purpose of this study was to investigate the effect of LDL and signal transduction inhibitor on the activation of platelets in Ischaemic risk subjects. Platelets from IHD and hyperlipidemic subjects were hypersensitive to ADP, as higher levels of platelet aggregation were observed in these groups. LDL from IHD hyperlipidemic subjects was more effective in activating platelets from any other group. Ox-LDL was more effective in activating platelets than native-LDL as monitored by level of platelet aggregation induced by PAF and thrombin. Calcium channel blocker, nifedipine and verapamil inhibited platelet aggregation at micromolar level. Protein kinase inhibitor, staurosporine was effective in inhibiting ADP induced aggregation at nanomolar level.