Plasma and cerebrospinal fluid pharmacokinetics of pemetrexed after intravenous administration in non-human primates
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- 作者：Stacie L. Stapleton ; Joel M. Reid ; Patrick A. Thompson ; Matthew M. Ames ; Renee M. McGovern ; Leticia McGuffey ; Jed Nuchtern ; Robert Dauser and Susan M. Blaney
- 关键词：Pemetrexed ; Antifol ; Antimetabolite ; CSF penetration ; Pharmacokinetics
- 刊名：Cancer Chemotherapy and Pharmacology
- 出版年：2007
- 出版时间：March, 2007
- 年：2007
- 卷：59
- 期：4
- 页码：461-466
- 全文大小：188 KB
文摘
Purpose Pemetrexed, a multi-targeted antifolate that disrupts synthesis of both purines and pyrimidines, is approved for use in malignant pleural mesothelioma and non-small cell lung cancer. Pemetrexed is currently being evaluated for anti-tumor activity in a variety of solid and central nervous system tumors. We studied the plasma and cerebrospinal fluid (CSF) pharmacokinetics of pemetrexed in a non-human primate model that is highly predictive of human CSF penetration.