Translational value of startle modulations

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• 作者：Markus Fendt ; Michael Koch
• 关键词：Anxiety disorders ; Endophenotypes ; Fear ; Prepulse ; inhibition ; Schizophrenia
• 刊名：Cell and Tissue Research
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：354
• 期：1
• 页码：287-295
• 全文大小：216KB
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• 作者单位：Markus Fendt (1)
  Michael Koch (2)
  
  1. Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany
  2. Brain Research Institute, Department of Neuropharmacology, University of Bremen, POB 330440, 28334, Bremen, Germany
  
• ISSN：1432-0878

文摘

The startle is a relatively simple ubiquitous reflex. Interestingly, it has a “non-zero baseline- i.e., its magnitude can be reduced or enhanced. We reflect here on the translational value of prepulse inhibition and fear-related potentiation as endophenotypes that can be used for the investigation of complex psychiatric diseases such as schizophrenia and anxiety-related disorders. Our main conclusions are that both phenomena of startle modulation are useful tools for basic research in investigating the genetic and/or neurobiological basis of certain aspects of these disorders. Because of their stable and robust nature, however, both biomarkers are of limited use for predicting the occurrence of diseases in high-risk people or for predicting the course of an illness.