'Papillary' solitary fibrous tumor/hemangiopericytoma with nuclear STAT6 expression and NAB2-STAT6 fusion

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• 作者：Keisuke Ishizawa ; Yoshitane Tsukamoto ; Shunsuke Ikeda…
• 关键词：Hemangiopericytoma ; NAB2 ; STAT6 fusion ; Papillary structure ; Solitary fibrous tumor ; STAT6 ; immunohistochemistry
• 刊名：Brain Tumor Pathology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：33
• 期：2
• 页码：151-156
• 全文大小：2,412 KB
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• 作者单位：Keisuke Ishizawa (1)
  Yoshitane Tsukamoto (2)
  Shunsuke Ikeda (3)
  Tomonari Suzuki (3)
  Taku Homma (1)
  Kazuhiko Mishima (3)
  Ryo Nishikawa (3)
  Atsushi Sasaki (1)
  
  1. Department of Pathology, Saitama Medical University, 38 Morohongo, Moroyama-town, Iruma-gun, Saitama, 350-0495, Japan
  2. Department of Surgical Pathology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan
  3. Department of Neurosurgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan
  
• 刊物主题：Neurosurgery; Neurology; Pathology; Oncology; Cancer Research;
• 出版者：Springer Japan
• ISSN：1861-387X

文摘

This report describes clinicopathological findings, including genetic data of STAT6, in a solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) of the central nervous system in an 83-year-old woman with a bulge in the left forehead. She noticed it about 5 months before, and it had grown rapidly for the past 1 month. Neuroradiological studies disclosed a well-demarcated tumor that accompanied the destruction of the skull. The excised tumor showed a prominent papillary structure, where atypical cells were compactly arranged along the fibrovascular core (‘pseudopapillary’). There was rich vasculature, some of which resembled ‘staghorn’ vessels. Mitotic figures were occasionally found. Whorls, psammoma bodies, or intra-nuclear pseudoinclusions were not identified. By immunohistochemistry, CD34 was strongly positive in the tumor cells, and STAT6 was localized in their nuclei. By reverse transcription-polymerase chain reaction (RT-PCR), an NAB2-STAT6 fusion gene, NAB2 exon6-STAT6 exon17, was detected, establishing a definite diagnosis of SFT/HPC. ‘Papillary’ SFT/HPC needs to be recognized as a possible morphological variant of SFT/HPC, and should be borne in mind in its diagnostic practice.