MK-801 and amphetamine result in dissociable profiles of cognitive impairment in a rodent paired associates learning task with relevance for schizophrenia

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• 作者：John Talpos ; Nancy Aerts ; Jason Waddell ; Thomas Steckler
• 关键词：NMDA receptor ; Dopamine receptor ; Touch screen ; PAL ; Memory ; Operant ; Schizophrenia
• 刊名：Psychopharmacology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：232
• 期：21-22
• 页码：3911-3920
• 全文大小：420 KB
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• 作者单位：John Talpos (1)
  Nancy Aerts (1)
  Jason Waddell (1)
  Thomas Steckler (1)
  
  1. Department of Neuroscience, Janssen Research and Development, 30 Turnhoutseweg, 2340, Beerse, Belgium
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale Paired associates learning (PAL) has been suggested to be predictive of functional outcomes in first episode psychosis and of conversion from mild cognitive impairment to Alzheimer’s disease. An automated touch screen-based rodent PAL (rPAL) task has been developed and is sensitive to manipulations of the dopaminergic and glutamatergic system. Accordingly, rPAL when used with pharmacological models of schizophrenia, like NMDA receptor blockade with MK-801 or dopaminergic stimulation with amphetamine, may have utility as a translational model of cognitive impairment in schizophrenia.