Prognostic value of coronary CT angiography on long-term follow-up of 6.9?years

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• 作者：Svetlana Dougoud (1)
  Tobias A. Fuchs (1)
  Julia Stehli (1)
  Olivier F. Clerc (1)
  Ronny R. Buechel (1)
  Bernhard A. Herzog (1)
  Sebastian Leschka (2) (4)
  Hatem Alkadhi (2)
  Philipp A. Kaufmann (1) (3)
  Oliver Gaemperli (1)
  
• 关键词：CT coronary angiography ; Prognosis ; Long ; term follow up
• 刊名：The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging)
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：30
• 期：5
• 页码：969-976
• 全文大小：
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• 作者单位：Svetlana Dougoud (1)
  Tobias A. Fuchs (1)
  Julia Stehli (1)
  Olivier F. Clerc (1)
  Ronny R. Buechel (1)
  Bernhard A. Herzog (1)
  Sebastian Leschka (2) (4)
  Hatem Alkadhi (2)
  Philipp A. Kaufmann (1) (3)
  Oliver Gaemperli (1)
  
  1. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
  2. Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland
  4. Institute of Radiology, Kantonsspital St. Gallen, St. Gallen, Switzerland
  3. Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland
  
• ISSN：1573-0743

文摘

Long term follow-up of coronary CT angiography (CCTA) is scarce. The aim of the present study was to?assess the prognostic value of CCTA over a follow-up period of more than 6?years. 218 Patients were included undergoing 64-slice CCTA. Images were analysed with regard to the presence of nonobstructive (<50?%) or obstructive (50?% stenosis) coronary artery disease (CAD). Major adverse cardiovascular events (MACE) were defined as death, nonfatal myocardial infarction or urgent coronary revascularization. CCTA revealed normal coronaries in 49, nonobstructive lesions in 94, and obstructive CAD in 75 patients. During a median follow-up period of 6.9?years, MACE occurred in 45 patients (21?%). Annual MACE rates were 0.3, 2.7, and 6.0?% (p?=?0.001), for patients with normal CCTA, nonobstructive, and obstructive CAD, respectively. Multivariate Cox regression analysis identified the number of segments with plaques [hazard ratio (HR) 1.18, p?=?0.002] as well as the presence of obstructive lesions (HR 2.28, p?=?0.036) as independent predictors of MACE. The present study extends the predictive value of CCTA over more than 6?years. Patients with normal coronary arteries of CCTA continue to have an excellent cardiac prognosis, while outcome is progressively worse in patients with nonobstructive and obstructive CAD.