Gender- and age-related differences in rest and post-stress left ventricular cardiac function determined by gated SPECT

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• 作者：Catherine Gebhard (1)
  Barbara E. St?hli (1)
  Caroline E. Gebhard (1)
  Michael Fiechter (1) (2)
  Tobias A. Fuchs (1)
  Julia Stehli (1)
  Bernd Klaeser (1)
  Felix C. Tanner (1) (2)
  Oliver Gaemperli (1)
  Philipp A. Kaufmann (1) (2)
  
• 关键词：Gated SPECT ; Left ventricular ejection fraction ; Gender ; Age
• 刊名：The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging)
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：30
• 期：6
• 页码：1191-1199
• 全文大小：521 KB
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• 作者单位：Catherine Gebhard (1)
  Barbara E. St?hli (1)
  Caroline E. Gebhard (1)
  Michael Fiechter (1) (2)
  Tobias A. Fuchs (1)
  Julia Stehli (1)
  Bernd Klaeser (1)
  Felix C. Tanner (1) (2)
  Oliver Gaemperli (1)
  Philipp A. Kaufmann (1) (2)
  
  1. Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
  2. Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland
  
• ISSN：1573-0743

文摘

Gender- and age-related changes of left ventricular (LV) function and dimensions have not been elucidated in a large population by gated SPECT. Thus, the aim of this study was to derive male and female reference limits for left ventricular functional parameters, and determine the effect of age on LV dimensions and systolic function for this imaging modality. 1,639 (53?% males) subjects without cardiovascular disease who underwent cardiac SPECT between January 2002 and June 2012 were included in this study. Mean age at presentation was 61?±?12?years (range 18-2?years). A significant effect of age (p?=?0.011) and gender (p?p?=?0.011). Overall, mean LVEF was higher in women compared to men (70.3?±?8.6?% vs. 64.4?±?7.5?%, p?p?=?0.01), which was the result of a significant increase in end-systolic volume after stress (p?=?0.0001). With advancing age an increase in LVEF was observed that was more pronounced in women than in men. These findings indicate that the evaluation of cardiac function and volumes of patients by gated SPECT should consider age- and gender-matched normative values.