Coronary artery calcium quantification from contrast enhanced CT using gemstone spectral imaging and material decomposition

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• 作者：Tobias A. Fuchs ; Julia Stehli…
• 关键词：Coronary CT angiography ; Calcium scoring ; Single ; source dual energy
• 刊名：The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging)
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：30
• 期：7
• 页码：1399-1405
• 全文大小：322 KB
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• 作者单位：Tobias A. Fuchs (1)
  Julia Stehli (1)
  Svetlana Dougoud (1)
  Bert-Ram Sah (1)
  Sacha Bull (1)
  Olivier F. Clerc (1)
  Mathias Possner (1)
  Ronny R. Buechel (1)
  Oliver Gaemperli (1)
  Philipp A. Kaufmann (1)
  
  1. Cardiac Imaging, Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
  
• ISSN：1573-0743

文摘

To explore the feasibility of coronary artery calcium (CAC) measurement from low-dose contrast enhanced coronary CT angiography (CCTA) as this may obviate the need for an unenhanced CT scan. 52 patients underwent unenhanced cardiac CT and prospectively ECG triggered contrast enhanced CCTA (Discovery HD 750, GE Healthcare, Milwaukee, WI, USA). The latter was acquired in single-source dual-energy mode [gemstone spectral imaging (GSI)]. Virtual unenhanced images were generated from GSI CCTA by monochromatic image reconstruction of 70?keV allowing selective iodine material suppression. CAC scores from virtual unenhanced CT were compared to standard unenhanced CT including a linear regression model. After iodine subtraction from the contrast enhanced CCTA the attenuation in the ascending aorta decreased significantly from 359?±?61 to 54?±?8?HU (P?P?=?ns) confirming successful iodine subtraction. After introducing linear regression formula the mean values for Agatston, Volume and Mass scores of virtual unenhanced CT were 187?±?321, 72?±?114?mm3, and 27?±?46?mg/cm3, comparing well to the values from standard unenhanced CT (187?±?309, 72?±?110?mm3, and 27?±?45?mg/cm3) yielding an excellent correlation (r?=?0.96, r?=?0.96, r?=?0.92; P?