Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue
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- 作者：Melanie Vanessa Heck (1)
Mekhman Azizov (1)
Tanja Stehning (1)
Michael Walter (2)
Nancy Kedersha (3)
Georg Auburger (1) - 关键词：TIA ; 1 ; Transcriptome ; Cell cycle ; Lipid trafficking ; RNA processing machinery ; Motor neuron disease ; Frontotemporal dementia ; Cerebellar ataxia
- 刊名：neurogenetics
- 出版年：2014
- 出版时间：May 2014
- 年：2014
- 卷：15
- 期：2
- 页码：135-144
- 全文大小：362 KB
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Mekhman Azizov (1)
Tanja Stehning (1)
Michael Walter (2)
Nancy Kedersha (3)
Georg Auburger (1)
1. Experimental Neurology, Department of Neurology, Goethe University Medical School, Building 89, 3rd floor, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
2. Institute for Medical Genetics, Eberhard-Karls-University of Tuebingen, 72076, Tübingen, Germany
3. Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA, 02115, USA - ISSN：1364-6753
文摘
During cell stress, the transcription and translation of immediate early genes are prioritized, while most other messenger RNAs (mRNAs) are stored away in stress granules or degraded in processing bodies (P-bodies). TIA-1 is an mRNA-binding protein that needs to translocate from the nucleus to seed the formation of stress granules in the cytoplasm. Because other stress granule components such as TDP-43, FUS, ATXN2, SMN, MAPT, HNRNPA2B1, and HNRNPA1 are crucial for the motor neuron diseases amyotrophic lateral sclerosis (ALS)/spinal muscular atrophy (SMA) and for the frontotemporal dementia (FTD), here we studied mouse nervous tissue to identify mRNAs with selective dependence on Tia1 deletion. Transcriptome profiling with oligonucleotide microarrays in comparison of spinal cord and cerebellum, together with independent validation in quantitative reverse transcriptase PCR and immunoblots demonstrated several strong and consistent dysregulations. In agreement with previously reported TIA1 knock down effects, cell cycle and apoptosis regulators were affected markedly with expression changes up to +2-fold, exhibiting increased levels for Cdkn1a, Ccnf, and Tprkb vs. decreased levels for Bid and Inca1 transcripts. Novel and surprisingly strong expression alterations were detected for fat storage and membrane trafficking factors, with prominent +3-fold upregulations of Plin4, Wdfy1, Tbc1d24, and Pnpla2 vs. a ?.4-fold downregulation of Cntn4 transcript, encoding an axonal membrane adhesion factor with established haploinsufficiency. In comparison, subtle effects on the RNA processing machinery included up to 1.2-fold upregulations of Dcp1b and Tial1. The effect on lipid dynamics factors is noteworthy, since also the gene deletion of Tardbp (encoding TDP-43) and Atxn2 led to fat metabolism phenotypes in mouse. In conclusion, genetic ablation of the stress granule nucleator TIA-1 has a novel major effect on mRNAs encoding lipid homeostasis factors in the brain, similar to the fasting effect.