Arterial remodeling of basilar atherosclerosis in isolated pontine infarction

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• 作者：Chao Feng (1) (2)
  Ting Hua (3)
  Yu Xu (3)
  Xue-Yuan Liu (1)
  Jing Huang (1)
  
  1. Department of Neurology ; Shanghai Tenth People鈥檚 Hospital of Tongji University ; Middle Yanchang Rd. 301# ; Zhabei District ; Shanghai ; China
  2. The Fourth Affiliated Hospital of Zhejiang University School of Medicine ; Yiwu ; Zhejiang ; China
  3. Department of Radiology ; Shanghai Tenth People鈥檚 Hospital of Tongji University ; Shanghai ; China
  
• 关键词：Paramedian pontine infarction ; Lacunar pontine infarction ; Basilar artery atherosclerosis ; Arterial remodeling ; High ; resolution MRI
• 刊名：Neurological Sciences
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：36
• 期：4
• 页码：547-551
• 全文大小：315 KB
• 参考文献：1. Chatzizisis, YS, Coskun, AU, Jonas, M (2007) Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol 49: pp. 2379-2393 CrossRef
  2. Cilla, M, Pena, E, Martinez, MA (2013) Comparison of the vulnerability risk for positive versus negative atheroma plaque morphology. J Biomech 46: pp. 1248-1254 CrossRef
  3. Feng, C, Xu, Y, Bai, X (2013) Basilar artery atherosclerosis and hypertensive small vessel disease in isolated pontine infarctions: a study based on high-resolution MRI. Eur Neurol 70: pp. 16-21 CrossRef
  4. Fujihara, K, Suzuki, H, Sato, A (2013) Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus. J Atheroscler Thromb 20: pp. 452-464 CrossRef
  5. Hong, MK, Park, SW, Lee, CW (2002) Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina: an intravascular ultrasound study. Clin Cardiol 25: pp. 225-229 CrossRef
  6. Hong, YJ, Jeong, MH, Choi, YH (2012) Positive remodeling is associated with vulnerable coronary plaque components regardless of clinical presentation: virtual histology-intravascular ultrasound analysis. Int J Cardiol 167: pp. 871-876 CrossRef
  7. Kashiwagi, M, Tanaka, A, Kitabata, H (2009) Relationship between coronary arterial remodeling, fibrous cap thickness and high-sensitivity C-reactive protein levels in patients with acute coronary syndrome. Circ J 73: pp. 1291-1295 CrossRef
  8. Klein, IF, Lavallee, PC, Mazighi, M (2010) Basilar artery atherosclerotic plaques in paramedian and lacunar pontine infarctions: a high-resolution MRI study. Stroke 41: pp. 1405-1409 CrossRef
  9. Lee, CW, Park, CS, Hwang, I (2011) Comparison of ruptured coronary plaques in patients with unstable and stable clinical presentation. J Thromb Thrombolysis 32: pp. 150-157 CrossRef
  10. Erro, ME, G谩llego, J, Herrera, M, Bermejo, B (2005) Isolated pontine infarcts: etiopathogenic mechanisms. Eur J Neurol 12: pp. 984-988 CrossRef
  11. Ma, N, Jiang, WJ, Lou, X (2010) Arterial remodeling of advanced basilar atherosclerosis: a 3-tesla MRI study. Neurology 75: pp. 253-258 CrossRef
  12. Marti-Carvajal, AJ, Sola, I, Lathyris, D (2013) Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev 1: pp. CD006612
  13. Matsuo, Y, Takumi, T, Mathew, V (2012) Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems. Atherosclerosis 223: pp. 365-371 CrossRef
  14. Miura, T, Matsukawa, N, Sakurai, K (2011) Plaque vulnerability in internal carotid arteries with positive remodeling. Cerebrovasc Dis Extra 1: pp. 54-65 CrossRef
  15. Reddy, HK, Koshy, SK, Wasson, S (2006) Adaptive-outward and maladaptive-inward arterial remodeling measured by intravascular ultrasound in hyperhomocysteinemia and diabetes. J Cardiovasc Pharmacol Ther 11: pp. 65-76 CrossRef
  16. Samady, H, Eshtehardi, P, McDaniel, MC (2011) Coronary artery wall shear stress is associated with progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease. Circulation 124: pp. 779-788 CrossRef
  17. Schartl, M, Bocksch, W, Fateh-Moghadam, S (2004) Effects of lipid-lowering therapy on coronary artery remodeling. Coron Artery Dis 15: pp. 45-51 CrossRef
  18. Schoenhagen, P, Nissen, SE, Tuzcu, EM (2003) Coronary arterial remodeling: from bench to bedside. Curr Atheroscler Rep 5: pp. 150-154 CrossRef
  19. Schoenhagen, P, Ziada, KM, Vince, DG (2001) Arterial remodeling and coronary artery disease: the concept of 鈥渄ilated鈥?versus 鈥渙bstructive鈥?coronary atherosclerosis. J Am Coll Cardiol 38: pp. 297-306 CrossRef
  20. Toyoda, K, Saku, Y, Ibayashi, S (1994) Pontine infarction extending to the basal surface. Stroke 25: pp. 2171-2178 CrossRef
  21. Xu, H, Liu, C, Wang, Q (2013) Plaque image characteristics, hyperhomocysteinemia, and gene polymorphism of homocysteine metabolism-related enzyme (MTHFR C677T) in acute coronary syndrome. Cell Biochem Biophys 66: pp. 403-407 CrossRef
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Neuroradiology
  Neurosurgery
  Psychiatry
  
• 出版者：Springer Milan
• ISSN：1590-3478

文摘

Isolated pontine infarctions are usually classified as paramedian pontine infarction (PPI) and lacunar pontine infarction (LPI). Although they have different shapes and locations, some recent studies proved that they might both be associated with basilar artery atherosclerosis in pathogenesis. This study aimed to explore the difference of basilar artery remodeling between two subtypes of pontine infarctions. Patients with PPI or LPI were scanned by High-resolution MRI (HR-MRI). The MR images of patients with basilar artery atherosclerosis were further analyzed to measure the vessel, lumen and wall areas at different segments of basilar arteries. Stenosis rate and remodeling index were calculated according to which arterial remodeling was divided into positive, intermediate and negative remodeling. Vascular risk factors and remodeling-related features were compared between PPI and LPI, and also between patients with and without positive remodeling. 34 patients with PPI and 21 patients with LPI had basilar artery atherosclerosis identified by HR-MRI. Positive remodeling was dominant in LPI group while in PPI group, three subtypes of remodeling were equal. Patients with positive remodeling had higher levels of low-density lipoprotein and homocysteine. Positive remodeling of basilar artery might reflect the low stability of basilar atherosclerotic plaques, which was more closely associated with LPI than PPI.