An integrated systems biology approach to the study of preterm birth using "-omic" technology - a guideline for research

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• 作者：Sara Gracie (1)
  Craig Pennell (2)
  Gunvor Ekman-Ordeberg (3)
  Stephen Lye (4)
  James McManaman (5)
  Scott Williams (6)
  Lyle Palmer (7)
  Maureen Kelley (8) (9)
  Ram Menon (10) (12)
  Michael Gravett (11) (9)
  
• 刊名：BMC Pregnancy and Childbirth
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：11
• 期：1
• 全文大小：591KB
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  55. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2393/11/71/prepub
  
• 作者单位：Sara Gracie (1)
  Craig Pennell (2)
  Gunvor Ekman-Ordeberg (3)
  Stephen Lye (4)
  James McManaman (5)
  Scott Williams (6)
  Lyle Palmer (7)
  Maureen Kelley (8) (9)
  Ram Menon (10) (12)
  Michael Gravett (11) (9)
  
  1. Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada
  2. School of Women鈥檚 and Infants鈥?Health, The University of Western Australia, Perth, Western Australia, Australia
  3. Division of Obstetrics and Gynecology, Department of Women鈥檚 and Children鈥檚 Health, Karolinska University Hospital and Karolinkska Institutet, Stockholm, Sweden
  4. Samuel Lunefeld Research Institute, University of Toronto, Toronto, Ontario, Canada
  5. Department of Obstetrics and Gynecology, Section of Basic Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
  6. Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA
  7. Ontario Institute for Cancer Research Toronto, Toronto, Ontario, Canada
  8. Department of Pediatrics, University of Washington School of Medicine and Treuman Katz Center for Pediatric Bioethics, Seattle, Washington, USA
  9. Global Alliance to Prevent Prematurity and Stillbirth, an initiative of Seattle Children鈥檚, Seattle, Washington, USA
  10. Department of Epidemiology, Emory University, Atlanta, Georgia
  12. The Perinatal Research Center, Nashville, Tennessee, USA
  11. Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington, USA
  

文摘

Preterm birth is the leading cause of neonatal mortality and perinatal morbidity. The etiology of preterm is multi-factorial and still unclear. As evidence increases for a genetic contribution to PTB, so does the need to explore genomics, transcriptomics, proteomics and metabolomics in its study. This review suggests research guidelines for the conduct of high throughput systems biology investigations into preterm birth with the expectation that this will facilitate the sharing of samples and data internationally through consortia, generating the power needed to study preterm birth using integrated "-omics" technologies. The issues to be addressed include: (1) integrated "-omics" approaches, (2) phenotyping, (3) sample collection, (4) data management-integrative databases, (5) international consortia and (6) translational feasibility. This manuscript is the product of discussions initiated by the "-Omics" Working Group at the Preterm Birth International Collaborative Meeting held at the World Health Organization, Geneva, Switzerland in April 2009.