Video Q&A: Rapid urine LAM test for HIV-associated TB - potential to reduce deaths? An interview with Stephen Lawn

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• 作者：Stephen D Lawn (1) (2)
  
• 刊名：BMC Medicine
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：11
• 期：1
• 全文大小：132KB
• 参考文献：1. Lawn SD: Point-of-care detection of lipoarabinomannan (LAM) in urine for diagnosis of HIV-associated tuberculosis: a state of the art review. / BMC Infect Dis 2012, 12:103. dx.doi.org/10.1186/1471-2334-12-103">CrossRef
  2. Lawn SD, Kerkhoff AD, Vogt M, Wood R: Diagnostic accuracy of a low-cost, urine antigen, point-of-care screening assay for HIV-associated pulmonary tuberculosis before antiretroviral therapy: a descriptive study. / Lancet Infect Dis 2012, 12:201鈥?09. dx.doi.org/10.1016/S1473-3099(11)70251-1">CrossRef
  3. Peter JG, Theron G, Zyl-Smit R, Haripersad A, Mottay L, Kraus S, Binder A, Meldau R, Hardy A, Dheda K: Diagnostic accuracy of a urine lipoarabinomannan strip-test for TB detection in HIV-infected hospitalised patients. / Eur Respir J 2012, 40:1211鈥?220. dx.doi.org/10.1183/09031936.00201711">CrossRef
  4. Lawn SD, Kerkhoff AD, Vogt M, Wood R: Clinical significance of lipoarabinomannan detection in urine using a low-cost point-of-care diagnostic assay for HIV-associated tuberculosis. / AIDS 2012, 26:1635鈥?643. dx.doi.org/10.1097/QAD.0b013e3283553685">CrossRef
  5. Shah M, Variava E, Holmes CB, Coppin A, Golub JE, McCallum J, Wong M, Luke B, Martin DJ, Chaisson RE, Dorman SE, Martinson NA: Diagnostic accuracy of a urine lipoarabinomannan test for tuberculosis in hospitalized patients in a High HIV prevalence setting. / J Acquir Immune Defic Syndr 2009, 52:145鈥?51. dx.doi.org/10.1097/QAI.0b013e3181b98430">CrossRef
  6. Lawn SD, Edwards DJ, Kranzer K, Vogt M, Bekker LG, Wood R: Urine lipoarabinomannan assay for tuberculosis screening before antiretroviral therapy diagnostic yield and association with immune reconstitution disease. / AIDS 2009, 23:1875鈥?880. dx.doi.org/10.1097/QAD.0b013e32832e05c8">CrossRef
  7. Minion J, Leung E, Talbot E, Dheda K, Pai M, Menzies D: Diagnosing tuberculosis with urine lipoarabinomannan: systematic review and meta-analysis. / Eur Respir J 2011, 38:1398鈥?405. dx.doi.org/10.1183/09031936.00025711">CrossRef
  8. Wood R, Racow K, Bekker LG, Middelkoop K, Vogt M, Kreiswirth BN, Lawn SD: Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria. / BMC Infect Dis 2012, 12:47. dx.doi.org/10.1186/1471-2334-12-47">CrossRef
  9. Lawn SD, Mwaba P, Bates M, Piatek A, Alexander H, Marais BJ, Cuevas LE, McHugh TD, Zijenah L, Kapata N, Abubakar I, McNerney R, Hoelscher M, Memish ZA, Migliori GB, Kim P, Maeurer M, Schito M, Zumla A: Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test. / Lancet Infect Dis 2013, 13:349鈥?61. dx.doi.org/10.1016/S1473-3099(13)70008-2">CrossRef
  10. Lawn SD, Churchyard G: Epidemiology of HIV-associated tuberculosis. / Curr Opin HIV AIDS 2009, 4:325鈥?33. dx.doi.org/10.1097/COH.0b013e32832c7d61">CrossRef
  11. The pre-publication history for this paper can be accessed here:dcentral.com/1741-7015/11/158/prepub" class="a-plus-plus">http://www.biomedcentral.com/1741-7015/11/158/prepub
  
• 作者单位：Stephen D Lawn (1) (2)
  
  1. Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
  2. Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
  

文摘

In this video Q&A, we talk to Dr Stephen Lawn about the point-of-care LAM test for HIV-associated TB, which has the potential to save lives by improving rapid diagnosis and treatment.