Detection of lipoarabinomannan (LAM) in urine is an independent predictor of mortality risk in patients receiving treatment for HIV-associated tuberculosis in sub-Saharan Africa: a systematic review and meta-analysis
详细信息 查看全文
- 作者：Ankur Gupta-Wright ; Jurgens A. Peters ; Clare Flach ; Stephen D. Lawn
- 关键词：HIV ; Tuberculosis ; Lipoarabinomannan ; LAM ; Mortality ; Systematic review
- 刊名：BMC Medicine
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：14
- 期：1
- 全文大小：1,528 KB
- 刊物主题：Medicine/Public Health, general; Biomedicine general;
- 出版者：BioMed Central
- ISSN：1741-7015
文摘
Background Simple immune capture assays that detect mycobacterial lipoarabinomannan (LAM) antigen in urine are promising new tools for the diagnosis of HIV-associated tuberculosis (HIV-TB). In addition, however, recent prospective cohort studies of patients with HIV-TB have demonstrated associations between LAM in the urine and increased mortality risk during TB treatment, indicating an additional utility of urinary LAM as a prognostic marker. We conducted a systematic review and meta-analysis to summarise the evidence concerning the strength of this relationship in adults with HIV-TB in sub-Saharan Africa, thereby quantifying the assay’s prognostic value.