Olfaction in chronic rhinosinusitis: comparing two different endonasal steroid application methods

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• 作者：Sophia C. Poletti ; Islam Batashev ; Jens Reden…
• 关键词：Nasal cavity ; Nose ; Olfactory mucosa ; Sinusitis ; Therapy ; Conventional nasal spray ; Pressure ; pulsed nasal inhalation
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：274
• 期：3
• 页码：1431-1435
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Otorhinolaryngology; Neurosurgery; Head and Neck Surgery;
• 出版者：Springer Berlin Heidelberg
• ISSN：1434-4726
• 卷排序：274

文摘

Limited olfactory improvement after topical steroid therapy in chronic rhinosinusitis (CRS) patients might result from restricted drug access to the olfactory cleft. The aim of our study was to investigate the difference between two methods to topically administer steroids with respect to olfaction: (1) conventional nasal spray and (2) a device using pressure and vibration to distribute steroid aerosol endonasally. A prospective study was performed in patients with olfactory impairment due to chronic rhinosinusitis with and without nasal polyps. While the first group used the conventional dexamethasone nasal spray, the second group used the device over a period of 12 days. Olfactory testing was done at 0, 2, and 8 weeks using Sniffin’ Sticks test. A significant olfactory improvement was found after 2 weeks of treatment with either steroid (p = 0.005). However, there was no significant difference between the different methods of steroid application. There is a significant olfactory improvement in CRS patients following topical dexamethasone therapy, but no obvious superiority of one of the two ways to administer the steroid.