Modeling leukocyte trafficking at the human blood-nerve barrier in vitro and in vivo geared towards targeted molecular therapies for peripheral neuroinflammation
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- 作者：Kelsey M. Greathouse ; Steven P. Palladino ; Chaoling Dong…
- 关键词：Blood ; nerve barrier ; Chronic inflammatory demyelinating polyradiculoneuropathy ; Experimental autoimmune neuritis ; Guillain ; Barré syndrome ; Intravital microscopy ; Leukocyte trafficking ; Neuropathic pain ; Spontaneous autoimmune peripheral polyneuropathy ; Two ; photon microscopy
- 刊名：Journal of Neuroinflammation
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：13
- 期：1
- 全文大小：2,369 KB
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Steven P. Palladino (1)
Chaoling Dong (1)
Eric S. Helton (1)
Eroboghene E. Ubogu (1)
1. Department of Neurology, Neuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, The University of Alabama at Birmingham, 1825 University Boulevard, Room 1131, Birmingham, AL, 35294-0017, USA - 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
- 出版者：BioMed Central
- ISSN：1742-2094
文摘
Peripheral neuroinflammation is characterized by hematogenous mononuclear leukocyte infiltration into peripheral nerves. Despite significant clinical knowledge, advancements in molecular biology and progress in developing specific drugs for inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis, there are currently no specific therapies that modulate pathogenic peripheral nerve inflammation. Modeling leukocyte trafficking at the blood-nerve barrier using a reliable human in vitro model and potential intravital microscopy techniques in representative animal models guided by human observational data should facilitate the targeted modulation of the complex inflammatory cascade needed to develop safe and efficacious therapeutics for immune-mediated neuropathies and chronic neuropathic pain. Keywords Blood-nerve barrier Chronic inflammatory demyelinating polyradiculoneuropathy Experimental autoimmune neuritis Guillain-Barré syndrome Intravital microscopy Leukocyte trafficking Neuropathic pain Spontaneous autoimmune peripheral polyneuropathy Two-photon microscopy