Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4
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- 作者：Max Leenders (1) (2)
Samsiddhi Bhattacharjee (3)
Paolo Vineis (1) (4)
Victoria Stevens (5)
H. Bas Bueno-de-Mesquita (2) (6)
Xiao-Ou Shu (7)
Laufey Amundadottir (3) (8)
Myron Gross (9)
Geoffrey S. Tobias (3)
Jean Wactawski-Wende (10)
Alan A. Arslan (11) (12) (13)
Eric J. Duell (14)
Charles S. Fuchs (15) (16)
Steven Gallinger (17)
Patricia Hartge (3)
Robert N. Hoover (3)
Elizabeth A. Holly (18)
Eric J. Jacobs (19)
Alison P. Klein (20) (21)
Charles Kooperberg (22)
Andrea LaCroix (5)
Donghui Li (23)
Margaret T. Mandelson (22) (24)
Sara H. Olson (25)
Gloria Petersen (26)
Harvey A. Risch (27)
Kai Yu (3)
Brian M. Wolpin (15) (16)
Wei Zheng (7)
Ilir Agalliu (28)
Demetrius Albanes (3)
Marie-Christine Boutron-Ruault (29)
Paige M. Bracci (18)
Julie E. Buring (30) (31)
Federico Canzian (32)
Kenneth Chang (33)
Stephen J. Chanock (3) (8)
Michelle Cotterchio (34) (35)
J. Michael Gaziano (36) (37)
Edward L. Giovanucci (16) (38) (39)
Michael Goggins (40)
G?ran Hallmans (41)
Susan E. Hankinson (16) (38)
Judith A. Hoffman-Bolton (42)
David J. Hunter (16) (38)
Amy Hutchinson (3) (43)
Kevin B. Jacobs (3) (43) (44)
Mazda Jenab (45)
Kay-Tee Khaw (46)
Peter Kraft (38) (47)
Vittorio Krogh (48)
Robert C. Kurtz (49)
Robert R. McWilliams (50)
Julie B. Mendelsohn (3)
Alpa V. Patel (5)
Kari G. Rabe (26)
Elio Riboli (1)
Anne Tj?nneland (51)
Dimitrios Trichopoulos (38) (52)
Jarmo Virtamo (53)
Kala Visvanathan (42)
Joanne W. Elena (54)
Herbert Yu (27)
Anne Zeleniuch-Jacquotte (12) (13)
Rachael Z. Stolzenberg-Solomon (3) - 关键词：Pancreatic cancer ; One ; carbon metabolism ; Polymorphisms ; Biomarkers ; Epidemiology
- 刊名：Cancer Causes and Control
- 出版年：2013
- 出版时间：March 2013
- 年：2013
- 卷：24
- 期：3
- 页码：595-602
- 全文大小：175KB
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32. Chuang S-C, Stolzenberg-Solomon R, Ueland PM et al (2011) A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. Eur J Cancer 47(12):1808-816 class="external" href="http://dx.doi.org/10.1016/j.ejca.2011.02.007">CrossRef - 作者单位：Max Leenders (1) (2)
Samsiddhi Bhattacharjee (3)
Paolo Vineis (1) (4)
Victoria Stevens (5)
H. Bas Bueno-de-Mesquita (2) (6)
Xiao-Ou Shu (7)
Laufey Amundadottir (3) (8)
Myron Gross (9)
Geoffrey S. Tobias (3)
Jean Wactawski-Wende (10)
Alan A. Arslan (11) (12) (13)
Eric J. Duell (14)
Charles S. Fuchs (15) (16)
Steven Gallinger (17)
Patricia Hartge (3)
Robert N. Hoover (3)
Elizabeth A. Holly (18)
Eric J. Jacobs (19)
Alison P. Klein (20) (21)
Charles Kooperberg (22)
Andrea LaCroix (5)
Donghui Li (23)
Margaret T. Mandelson (22) (24)
Sara H. Olson (25)
Gloria Petersen (26)
Harvey A. Risch (27)
Kai Yu (3)
Brian M. Wolpin (15) (16)
Wei Zheng (7)
Ilir Agalliu (28)
Demetrius Albanes (3)
Marie-Christine Boutron-Ruault (29)
Paige M. Bracci (18)
Julie E. Buring (30) (31)
Federico Canzian (32)
Kenneth Chang (33)
Stephen J. Chanock (3) (8)
Michelle Cotterchio (34) (35)
J. Michael Gaziano (36) (37)
Edward L. Giovanucci (16) (38) (39)
Michael Goggins (40)
G?ran Hallmans (41)
Susan E. Hankinson (16) (38)
Judith A. Hoffman-Bolton (42)
David J. Hunter (16) (38)
Amy Hutchinson (3) (43)
Kevin B. Jacobs (3) (43) (44)
Mazda Jenab (45)
Kay-Tee Khaw (46)
Peter Kraft (38) (47)
Vittorio Krogh (48)
Robert C. Kurtz (49)
Robert R. McWilliams (50)
Julie B. Mendelsohn (3)
Alpa V. Patel (5)
Kari G. Rabe (26)
Elio Riboli (1)
Anne Tj?nneland (51)
Dimitrios Trichopoulos (38) (52)
Jarmo Virtamo (53)
Kala Visvanathan (42)
Joanne W. Elena (54)
Herbert Yu (27)
Anne Zeleniuch-Jacquotte (12) (13)
Rachael Z. Stolzenberg-Solomon (3)
1. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK
2. Department of Gastroenterology and Hepatology, University Medical Center Utrecht, F02.618, Postal Box 85500, 3508GA, Utrecht, The Netherlands
3. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
4. HuGeF Foundation, Turin, Italy
5. Department of Epidemiology, American Cancer Society, Atlanta, GA, USA
6. National Institute for Public Health and the Environment, Bilthoven, The Netherlands
7. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
8. Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
9. Department of Laboratory Medicine/Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA
10. Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
11. Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, USA
12. Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
13. New York University Cancer Institute, New York, NY, USA
14. Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain
15. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
16. Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
17. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
18. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
19. Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA
20. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
21. Department of Epidemiology, Johns Hopkins Medical Institutions, The Bloomberg School of Public Heath, The Sol Goldman Pancreatic Research Center, Baltimore, MD, USA
22. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
23. Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
24. Group Health Center for Health Studies, Seattle, WA, USA
25. Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
26. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
27. Yale University School of Public Health, New Haven, CT, USA
28. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
29. INSERM, Institut Gustave-Roussy, Paris-Sud University, Villejuif, France
30. Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
31. Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA, USA
32. Division of Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany
33. Comprehensive Digestive Disease Center, University of California, Irvine Medical Center, Orange, CA, USA
34. Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
35. Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada
36. Physicians-Health Study, Divisions of Aging, Cardiovascular Medicine, and Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
37. Veterans Affairs Boston Healthcare System, Massachusetts Veterans Epidemiology Research and Information Center, Boston, MA, USA
38. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
39. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
40. Departments of Oncology, Pathology and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
41. Department of Public Health and Clinical Medicine, Nutritional Research, Ume? University, Ume?, Sweden
42. Department of Epidemiology, The Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
43. Core Genotyping Facility, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA
44. Bioinformed Consulting Services, Gaithersburg, MD, USA
45. International Agency for Research on Cancer (IARC/WHO), Lyon, France
46. Department of Public Health and Primary Care, Clinical Gerontology, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK
47. Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
48. Nutritional Epidemiology Unit, Fondazione Istituto di Recovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan, Italy
49. Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
50. Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA
51. Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
52. Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece
53. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
54. Division of Cancer Prevention and Population Control, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA - ISSN：1573-7225
文摘
Purpose The evidence of a relation between folate intake and one-carbon metabolism (OCM) with pancreatic cancer (PanCa) is inconsistent. In this study, the association between genes and single-nucleotide polymorphisms (SNPs) related to OCM and PanCa was assessed. Methods Using biochemical knowledge of the OCM pathway, we identified thirty-seven genes and 834 SNPs to examine in association with PanCa. Our study included 1,408 cases and 1,463 controls nested within twelve cohorts (PanScan). The ten SNPs and five genes with lowest p values (<0.02) were followed up in 2,323 cases and 2,340 controls from eight case–control studies (PanC4) that participated in PanScan2. The correlation of SNPs with metabolite levels was assessed for 649 controls from the European Prospective Investigation into Cancer and Nutrition. Results When both stages were combined, we observed suggestive associations with PanCa for rs10887710 (MAT1A) (OR 1.13, 95?%CI 1.04-.23), rs1552462 (SYT9) (OR 1.27, 95?%CI 1.02-.59), and rs7074891 (CUBN) (OR 1.91, 95?%CI 1.12-.26). After correcting for multiple comparisons, no significant associations were observed in either the first or second stage. The three suggested SNPs showed no correlations with one-carbon biomarkers. Conclusions This is the largest genetic study to date to examine the relation between germline variations in OCM-related genes polymorphisms and the risk of PanCa. Suggestive evidence for an association between polymorphisms and PanCa was observed among the cohort-nested studies, but this did not replicate in the case–control studies. Our results do not strongly support the hypothesis that genes related to OCM play a role in pancreatic carcinogenesis.