Abatacept Does Not Induce Direct Gene Expression Changes in Antigen-Presenting Cells
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- 作者：Julie A. Carman ; Patricia M. Davis ; Wen-Pin Yang ; Jun Zhu ; Han Chang ; Aiqing He ; Amy Truong ; Suzanne J. Suchard and Steven G. Nadler
- 关键词：abatacept ; belatacept ; costimulation ; gene expression
- 刊名：Journal of Clinical Immunology
- 出版年：2009
- 出版时间：July, 2009
- 年：2009
- 卷：29
- 期：4
- 页码：479-489
- 全文大小：397.1 KB
文摘
Background It has been proposed that ligation of CD80 and CD86 induces reverse signaling into antigen-presenting cells. In this study, we tested the ability of abatacept, a soluble human fusion protein comprising the extracellular domain of cytotoxic T lymphocyte antigen 4 and a fragment of the Fc domain of IgG1, to activate antigen-presenting cells by measuring changes in global transcriptional responses.