Association of serum bilirubin and uric acid levels changes during neuroinflammation in patients with initial and relapsed demyelination attacks

详细信息    查看全文

• 作者：Srdjan Ljubisavljevic (1) (2) (5)
  Ivana Stojanovic (3)
  Slobodan Vojinovic (1)
  Maja Milojkovic (2)
  Olivera Dunjic (2)
  Dragan Stojanov (4)
  Dusica Pavlovic (3)
  
• 关键词：Bilirubin ; Uric acid ; Clinically isolated syndrome ; Relapsing remitting multiple sclerosis
• 刊名：Metabolic Brain Disease
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：28
• 期：4
• 页码：629-638
• 全文大小：
• 作者单位：Srdjan Ljubisavljevic (1) (2) (5)
  Ivana Stojanovic (3)
  Slobodan Vojinovic (1)
  Maja Milojkovic (2)
  Olivera Dunjic (2)
  Dragan Stojanov (4)
  Dusica Pavlovic (3)
  
  1. Clinic of Neurology, Clinical Centre Nis, Bul. Dr Zorana Djindjica 48, 18000, Nis, Serbia
  2. Institute for Pathophysiology, Faculty of Medicine, University of Nis, Bul. Dr Zorana Djindjica 81, 18000, Nis, Serbia
  5. Faculty of Medicine, University of Nis, Bul. Dr Zorana Djindjica 81, 18000, Nis, Serbia
  3. Institute for Biochemistry, Faculty of Medicine, University of Nis, Bul. Dr Zorana Djindjica 81, 18000, Nis, Serbia
  4. Center for Radiology, Clinical Centre Nis, Bul. Dr Zorana Djindjica 48, 18000, Nis, Serbia
  
• ISSN：1573-7365

文摘

In order to examine the endogenous antioxidants values in the earliest phase of demyelination, we have determined bilirubin and uric acid (UA) serum values in the patients with clinically isolated syndrome (CIS) and relapsing remitting multiple sclerosis (RRMS), regarding their clinical disability, measured by Extended Disability Status Scale (EDSS), Magnetic Resonance Imaging (MRI), disease duration, gender and other parameters. The bilirubin and UA levels were lower in CIS and RRMS patients than in control group, whether male or female (p?<?0.05). The bilirubin and UA levels were decreased in RRMS compared to CIS patients (p?<?0.05). Regarding EDSS, MRI and disease duration, obtained values of bilirubin and UA were higher in both study groups in patients with lower EDSS, lower MRI lesion number and shorter disease duration (p?<?0.05). The greatest significance in decreased bilirubin and UA levels was observed in female compared to male patients, in both study groups (p?<?0.05). The results suggest negative linear correlation between bilirubin and UA levels and disease duration, EDSS and MRI in CIS (p?<?0.01), with the same correlation between bilirubin and UA levels and disease duration in RRMS patients (p?<?0.01). There was also significant correlation between bilirubin level and MRI findings and UA levels and EDSS in RRMS patients (p?<?0.01). The obtained results point to the importance of endogenous antioxidants in the outbreak and course of neuroinflammation. This could be favorable for the new pathogenetically conditioned neuroinflammatory therapy concepts which do not initially rely only on immunomodulatory, but also on the antioxidative effects.