Calcium stone disease: a multiform reality

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• 作者：Alberto Trinchieri ; Chiara Castelnuovo ; Renata Lizzano and Giampaolo Zanetti
• 关键词：Renal calcium oxalate stone ; Urinary calcium ; Calcium oxalate monohydrate ; Calcium oxalate dihydrate ; Apatite ; Uric acid
• 刊名：Urological Research
• 出版年：2005
• 出版时间：June 2005
• 年：2005
• 卷：33
• 期：3
• 页码：194-198
• 全文大小：190 KB

文摘

In calcium renal stones, calcium oxalate and calcium phosphate in various crystal forms and states of hydration can be identified. Calcium oxalate monohydrate (COM) or whewellite and calcium oxalate dihydrate (COD) or weddellite are the commonest constituents of calcium stones. Calcium oxalate stones may be pure or mixed, usually with calcium phosphate or sometimes with uric acid or ammonium urate. The aim of this study was to compare the clinical and urinary patterns of patients forming calcium stones of different composition according to infrared spectroscopic analysis in order to obtain an insight into their etiology. The stones of 84 consecutive calcium renal stone formers were examined by infrared spectroscopy. In each patient, a blood sample was drawn and analysed for serum biochemistry and a 24-h urine sample was collected and analysed for calcium, phosphate, oxalate, citrate and other electrolytes. We classified 49 patients as calcium oxalate monohydrate (COM) stone formers, 32 as calcium oxalate dihydrate (COD) stone formers and three as apatite stone formers according to the main component of their stones. Patients with COM stones were significantly older than patients with COD stones (PP10 % ) presented with higher saturation (P P P15 % ) showed higher (PPPP15 % , higher urinary pH (PPcalcium stones could require various approaches dependent on the form and hydration of the calcium crystals in their stones, and on the presence of minor crystalline components that could have acted as epitaxial factors.