Epstein–Barr virus-associated inflammatory pseudotumor of the spleen: report of two cases and review of the literature

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• 作者：Lizabeth Rosenbaum (1)
  M. Houman Fekrazad (2)
  Ian Rabinowitz (2)
  Mohammad A. Vasef (1) (3)
  
• 关键词：Splenic inflammatory pseudotumor ; Epstein–Barr virus ; Follicular dendritic cell
• 刊名：Journal of Hematopathology
• 出版年：2009
• 出版时间：July 2009
• 年：2009
• 卷：2
• 期：2
• 页码：127-131
• 全文大小：408KB
• 参考文献：1. Neuhauser TS, Derringer GA, Thompson LDR, Fanburg-Smith JC, Aguilera NSI, Andriko J, Chu W-S, Abbondanzo SL (2001) Splenic inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunophenotypic study of 12 cases. Arch Path Lab Med 125:79-5
  2. Noguchi H, Kondo H, Kondo M, Shiraiwa M, Monobe Y (2000) Inflammatory pseudotumor of the spleen. A case report. Jpn J Clin Oncol 30:196-03 CrossRef
  3. Chen WH, Liu TP, Liu CL, Tzen CY (2004) Inflammatory pseudotumor of the spleen. J Chin Med Assoc 67:533-36
  4. Oshiro H, Nomura M, Yamanaka S, Watanabe S, Inayama Y (2007) Splenic inflammatory pseudotumor (inflammatory myofibroblastic tumor). J Clin Exp Hematopathol 47:83-8 CrossRef
  5. Horiguchi H, Matsui-Horiguchi M, Sakta H, Ichinose M, Yamamoto T, Fujiwara M, Ohse H (2004) Inflammatory pseudotumor-like follicular dendritic cell tumor of the spleen. Pathol Inter 54:124-31 CrossRef
  6. Oz Puyan F, Bilgi S, Unlu E, Yalcin O, Altaner S, Demir M, Cakir B (2004) Inflammatory pseudotumor of the spleen with EBV positivity. Report of a case. Eur J Haematol 72:285-91 CrossRef
  7. Cheuk W, Chan JKC, Shek TWH et al (2001) Inflammatory pseudotumor-like follicular dendritic cell tumor. A distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association. Am J Surg Pathol 25:721-31 CrossRef
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  9. Arber DA, Weiss LM, Chang KL (1998) Detection of Epstein-Barr virus in inflammatory pseudotumor. Semin Diagn Pathol 15:155-60
  10. Lewis JT, Gaffney RL, Casey MB, Farrell MA, Morice WG, Macon WR (2003) Inflammatory pseudotumor of the spleen associated with a clonal Epstein-Barr virus genome. Case report and review of the literature. Am J Clin Path 120:56-1 CrossRef
  11. Kutok JL, Pinkus GS, Dorfman DM, Fletcher CDM (2001) Inflammatory pseudotumor of lymph node and spleen. An entity biologically distinct from inflammatory myofibroblastic tumor. Hum Pathol 32:1382-387 CrossRef
  12. Selves J, Meggetto F, Brousset P et al (1996) Inflammatory pseudotumor of the liver. Evidence for follicular dendritic reticulum cell proliferation associated with clonal Epstein-Barr virus. Am J Surg Pathol 20:747-53 CrossRef
  13. Shek TW, Ho FC, Ng IO et al (1996) Follicular dendritic cell tumor of the liver. Evidence for an Epstein-Barr virus-related clonal proliferation of follicular dendritic cells. Am J Surg Pathol 20:313-24 CrossRef
  
• 作者单位：Lizabeth Rosenbaum (1)
  M. Houman Fekrazad (2)
  Ian Rabinowitz (2)
  Mohammad A. Vasef (1) (3)
  
  1. Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
  2. Department of Internal Medicine, Division of Hematology/Oncology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
  3. Department of Pathology MSC08 4640, 1 University of New Mexico, Albuquerque, NM, 87131, USA
  

文摘

We report two rare examples of Epstein–Barr virus (EBV)-associated inflammatory pseudotumor of the spleen. One patient presented with night sweats, abdominal pain, and weight loss and was found to have a splenic mass on CT scan suspected of lymphoma. The splenic mass in second patient was found incidentally at the time of work up for kidney stones. The pathologic examination of these splenectomy specimens showed similar histologic features. However, the spindle cells were composed of EBV-infected follicular dendritic cells in one case whereas the second case lacked significant follicular dendritic cell proliferation and showed only focal EBV-infected cells suggesting that these proliferations are heterogenous in nature.