Stimulant Reduction Intervention using Dosed Exercise (STRIDE) - CTN 0037: Study protocol for a randomized controlled trial

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• 作者：Madhukar H Trivedi (1)
  Tracy L Greer (1)
  Bruce D Grannemann (1)
  Timothy S Church (2)
  Eugene Somoza (3)
  Steven N Blair (4) (5)
  Jose Szapocznik (6)
  Mark Stoutenberg (6)
  Chad Rethorst (1)
  Diane Warden (1)
  Kolette M Ring (1)
  Robrina Walker (1)
  David W Morris (1)
  Andrzej S Kosinski (7)
  Tiffany Kyle (8)
  Bess Marcus (9)
  Becca Crowell (10)
  Neal Oden (11)
  Edward Nunes (12)
  
• 关键词：stimulant abuse ; stimulant dependence ; exercise ; health education ; behavioral intervention
• 刊名：Trials
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：12
• 期：1
• 全文大小：419KB
• 参考文献：1. Dutra L, Stathopoulou G, Basden SL, Leyro TM, Powers MB, Otto MW: A metaanalytic review of psychosocial interventions for substance user disorders. / American Journal of Psychiatry 2008, 165:179-87. CrossRef
  2. Ball SA, Martino S, Nich C, Frankforter TL, Van Horn D, Crits-Christoph P, Woody GE, Obert JL, Farentinos C, Carroll KM: Site matters: Multisite randomized trial of motivational enhancement therapy in community drug abuse clinics. / Journal of Consulting and Clinical Psychology 2007, 75:556-67. CrossRef
  3. Carroll KM, Ball SA, Nich C: Motivational interviewing to improvement treatment engagement and outcome in individuals seeking treatment for substance abuse: A multisite effectiveness study. / Drug and Alcohol Dependence 2006, 80:301-12. CrossRef
  4. Rawson RA, McCann MJ, Flammino F, Shoptaw S, Miotto K, Reiber C, Ling W: A comparison of contingency management and cognitive behavioral approaches for stimulant-dependent individuals. / Addiction 2006, 101:267-74. CrossRef
  5. Wetzel H, Szegedi A, Scheurich A, Lorch B, Schlafke D, Sittinger H, Wobrock T, Muller MJ, Anghelescu I, Hautzinger M, NeVeR Study Group: Combination treatment with nefazodone and cognitive-behavioral therapy for relapse prevention in alcohol-dependent men: A randomized controlled study. / Journal of Clinical Psychiatry 2004, 65:1406-413. CrossRef
  6. Vocci FJ, Montoya ID: Psychological treatments for stimulant misuse, comparing and contrasting those for amphetamine dependence and those for cocaine dependence. / Current Opinion in Psychiatry 2009,22(3):263-68. CrossRef
  7. Marcus BH, Albrecht AE, King TK, Parisi AF, Pinto BM, Roberts M: Exercise effects on withdrawal and mood among women attempting smoking cessation. / Archives of Internal Medicine 1999, 159:1229-234. CrossRef
  8. Marcus BH, Albrecht AE, Niaura RS, Abrams DB, Thompson PD: Usefulness of physical exercise for maintaining smoking cessation in women. / American Journal of Cardiology 1991, 68:406-07. CrossRef
  9. Marcus BH, Albrecht AE, Niaura RS, Taylor ER, Simkin LF, Feder SI: Exercise enhances the maintenance of smoking cessation in women. / Addictive Behaviors 1995, 20:87-5. CrossRef
  10. Marcus BH, Lewis BA, Hogan J, King TK, Albrecht AE, Bock BC, Parisi AF, Niaura RS, Abrams DB: The efficacy of moderate-intensity exercise as an aid for smoking cessation in women: a randomized controlled trial. / Nicotine & Tobacco Research 2005, 7:871-80. CrossRef
  11. Martin JE, Calfas KJ, Patten CA, Polarek M, Hofstetter CR, Noto J, Beach D: Prospective evaluation of three smoking interventions in 205 recovering alcoholics: One-year results of project SCRAP-Tobacco. / Journal of Consulting and Clinical Psychology 1997, 65:190-94. CrossRef
  12. Sinyor D, Brown T, Rostant L, Seraganian P: The role of a physical fitness program in the treatment of alcoholism. / Journal of Studies on Alcohol 1982, 43:380-86.
  13. Collingwood TR, Reynolds R, Kohl HW, Smith W, Sloan S: Physical fitness effects on substance abuse risk factors and use patterns. / Journal of Drug Education 1991, 21:73-4. CrossRef
  14. Collingwood TR, Sunderlin J, Kohl HW: The use of a staff training model for implementing fitness programming to prevent substance abuse with at-risk youth. / American Journal of Health Promotion 1994, 9:20-3. 33
  15. Petry NM, Alessi SM, Marx J, Austin M, Tardiff M: Vouchers versus prizes: Contingency management treatment of substance abusers in community settings. / Journal of Consulting and Clinical Psychology 2005, 73:1005-014. CrossRef
  16. Petry NM, Tedford J, Austin M, Nich C, Carroll KM, Rounsaville BJ: Prize reinforcement contingency management for treatment of cocaine abusers: How low can we go and with whom? / Addiction 2004, 99:349-60. CrossRef
  17. Weinstock J, Barry D, Petry NM: Exercise-related activities are associated with positive outcome in contingency management treatment for substance use disorders. / Addictive Behaviors 2008,3(8):1072-075. CrossRef
  18. Brown RA, Abrantes AM, Read JP, Marcus BH, Jakicic J, Strong DR, Oakley JR, Ramsey SE, Kahler CW, Stuart GG, Dubreuil ME, Gordon AA: A pilot study of aerobic exercise as an adjunctive treatment for drug dependence. / Mental Health and Physical Activity 2010, 3:27-4. CrossRef
  19. Frankel A, Murphy J: Physical fitness and personality in alcoholism. / Quarterly Journal of Studies on Alcohol 1974, 35:1272-278.
  20. Palmer J, Palmer LK, Michiels K, Thigpen B: Effects of type of exercise on depression in recovering substance abusers. / Perceptual and Motor Skills 1995, 80:523-30. CrossRef
  21. Palmer J, Vacc N, Epstein J: Adult inpatient alcoholics: Physical exercise as a treatment intervention. / Journal of Studies on Alcohol and Drugs 1988, 49:418-21.
  22. Bock BC, Marcus BH, King TK, Borrelli B, Roberts MR: Exercise effects on withdrawal and mood among women attempting smoking cessation. / Addictive Behaviors 1999, 24:399-10. CrossRef
  23. Kawachi I, Troisi RJ, Rotnitsky AG, Coakley EH, Colditz MD: Can physical activity minimize weight gain in women after smoking cessation? / American Journal of Public Health 1996, 86:999-004. CrossRef
  24. Taylor CB, Sallis JF, Needle R: The relation of physical activity and exercise to mental health. / Public Health Reports 1985, 100:195-01.
  25. Martin CK, Church TS, Thompson AM, Earnest CP, Blair SN: Exercise dose and quality of life. / Archives of Internal Medicine 2009, 169:269-78. CrossRef
  26. Youngstedt SD: Effects of exercise on sleep. / Clinical Sports Medicine 2005,24(2):355-65. xi CrossRef
  27. Borders TF, Booth BM, Falck RS, Leukefeld C, Wang J, Carlson RG: Longitudinal changes in drug use severity and physical health-related quality of life among untreated stimulant users. / Addictive Behaviors 2009, 34:959-64. CrossRef
  28. Morgan PT, Pace-Schott EF, Sahul ZH, Coric V, Stickgold R, Malison RT: Sleep, sleep-dependent procedural learning and vigilance in chronic cocaine users: Evidence for occult insomnia. / Drug and Alcohol Dependence 2006, 82:238-49. CrossRef
  29. Cowan J, Devine C: Food, eating, and weight concerns of men in recovery from substance addiction. / Appetite 2008, 50:33-2. CrossRef
  30. Hodgkins CC, Cahill KS, Seraphine AE, Frost-Pineda K, Gold MS: Adolescent drug addiction treatment and weight gain. / Journal of Addictive Disorders 2004, 23:55-6. CrossRef
  31. Hodgkins CC, Jacobs WS, Gold MS: Weight gain after adolescent drug addiction treatment and supervised abstinence. / Psychiatric Annals 2003, 33:112-16.
  32. Greenwood BN, Strong PV, Foley TE, Fleshner M: A behavioral analysis of the impact of voluntary physical activity on hippocampus-dependent contextual conditioning. / Hippocampus 2009, 19:988-001. CrossRef
  33. Clark PJ, Brzezinska WJ, Thomas MW, Ryzhenko NA, Toshkov SA, Rhodes JS: Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice. / Neuroscience 2008, 155:1048-058. CrossRef
  34. Gomez-Pinilla F, Vaynman S, Ying Z: Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. / European Journal of Neuroscience 2008, 28:2278-287. CrossRef
  35. Wojtowicz JM, Askew ML, Winocur G: The effects of running and of inhibiting adult neurogenesis on learning and memory in rats. / European Journal of Neuroscience 2008, 27:1494-502. CrossRef
  36. Bolla KI, Rothman R, Cadet JL: Dose-related neurobehavioral effects of chronic cocaine use. / Journal of Neuropsychiatry and Clinical Neurosciences 1999, 11:361-69.
  37. Meeusen R: Exercise and the brain: insight in new therapeutic modalities. / Annals of Transplantation 2005, 10:49-1.
  38. Crews DJ, Landers DM: A meta-analytic review of aerobic fitness and reactivity to psychosocial stressors. / Medicine & Science in Sports & Exercise 1987,19(5 suppl):S114-20.
  39. Rejeski WJ, Gregg E, Thompson A, Berry M: The effects of varying doses of acute aerobic exercise on psychophysiological stress responses in highly trained cyclists. / Journal of Sport & Exercise Psychology 1991, 13:188-99.
  40. McAuley E, Courneya KS, Lettunich J: Effects of acute and long-term exercise on self-efficacy responses in sedentary, middle-aged males and females. / The Gerontologist 1991, 31:534-42. CrossRef
  41. Williams PA, Cash TF: A controlled study of the effects of circuit weight training on body image. Paper presented at the Annual meeting of the Association for the Advancement of Behavior Therapy, Toronto, Ontario. 1999.
  42. Breus MJ, O'Connor PJ: Exercise induced anxiolysis: a test of the "time out" hypothesis in high-anxious females. / Medicine & Science in Sports & Exercise 1998, 30:1107-112. CrossRef
  43. Ussher M, Sampuran AK, Doshi R, West R, Drummond DC: Acute effect of a brief bout of exercise on alcohol urges. / Addiction 2004, 99:1542-547. CrossRef
  44. Marlatt GA, Gordon JR: / Relapse prevention: Maintenance strategies in the treatment of addictive behaviors. New York: Guilford Press; 1985.
  45. Smith E, Meyers RJ, eds: / The community reinforcement approach. New York: Guilford Press; 1995.
  46. Trivedi MH, Greer TL, Potter JS, Grannemann BD, Nunes EV, Rethorst CD, Warden D, Ring KM, Somoza E: Determining the primary endpoint for a stimulant abuse trial: Lessons learned from STRIDE (CTN 0037). / The American Journal of Drug and Alcohol Abuse 2011, 37:339-49. CrossRef
  47. Warden D, Trivedi MH, Greer TL, Nunes EV, Grannemann BD, Horigian VE, Somoza E, Ring KM, Kyle T, Szapocznik J: Rationale and methods for site selection for a trial using a novel intervention to treat stimulant abuse. / Contemporary Clinical Trials, in press.
  48. Sobell LC, Sobell MB, eds: / Timeline follow-back: A technique for assessing self-reported alcohol consumption. Totowa: Humana Press; 1992.
  49. Sobell LC, Sobell MB: / Timeline Followback user's guide: A calendar method for assessing alcohol and drug use. Toronto: Addiction Research Foundation; 1996.
  50. Oden NL, VanVeldhuisen PC, Wakim PG, Trivedi MH, Somoza E, Lewis D: Power of automated algorithms for combining Time-Line Follow-Back and urine drug screening test results in stimulant-abuse clinical trials. / American Journal of Drug and Alcohol Abuse 2011, 37:350-57. CrossRef
  51. / ACSM's Guidelines for Exercise Testing and Prescription 8th edition. Lippincott Williams & WIlkins; 2010.
  52. Rejeski WJ, Fielding RA, Blair SN, Guralnik JM, Gill TM, Hadley EC, King AC, Kritchevsky SB, Miller ME, Newman AB, Pahor M: The lifestyle interventions and independence for elders (LIFE) pilot study: Design and methods. / Contemporary Clinical Trials 2005, 26:141-54. CrossRef
  53. LIFE Study Investigators, Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, King AC, Kritchevsky SB, Maraldi C, Miller ME, Newman AB, Rejeski WJ, Romashkan S, Studenski S: Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. / The Journals of Gerontology, Biological Sciences and Medical Sciences: Series A 2006, 61:1157-165.
  54. Trivedi MH, Greer TL, Grannemann BD, Church TS, Galper DI, Sunderajan P, Wisniewski SR, Chambliss HO, Jordan AN, Finley C, Carmody TJ: TREAD: Treatment with exercise augmentation for depression: Study rationale and design. / Clinical Trials 2006, 3:291-05. CrossRef
  55. Robins LN, Wing J, Wittchen HU, Helzer JE, Babor TF, Burke J, Farmer A, Jablensky A, Pickens R, Regier DA, Sartorius N, Towle LH: The Composite International Diagnostic Interview: An epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. / Archives of General Psychiatry 1988, 45:1069-077.
  56. WHO: / Composite International Diagnostic Interview, version 2.1. Geneva: World Health Organization; 1997.
  57. Sheehan DV, Lecrubier Y, Harnett-Sheehan K, Janavs J, Weiller E, Keskiner A, Schinka J, Knapp E, Sheehan MF, Dunbar GC: Reliability and validity of the MINI International Neuropsychiatric Interview (M.I.N.I.): According to the SCID-P. / European Psychiatry 1997, 12:232-41. CrossRef
  58. Sangha O, Stucki G, Liang MH, Fossel AH, Katz JN: The Self-Administered Comorbidity Questionnaire: A new method to assess comorbidity for clinical and health services research. / Arthritis & Rheumatism 2003, 49:156-63. CrossRef
  59. Canadian Society for Exercise Physiology (CSEP): Physical Activity Readiness Questionnaire (PAR-Q). [http://www.csep.ca/forms.asp] 2002.
  60. McLellan AT, Luborsky L, Woody GE, O'Brien CP: An improved diagnostic evaluation instrument for substance abuse patients. The Addiction Severity Index. / Journal of Nervous and Mental Disease 1980, 168:26-3. CrossRef
  61. Sussner BD, Smelson DA, Rodrigues S, Kline A, Losonczy M, Ziedonis D: The validity and reliability of a brief measure of cocaine craving. / Drug and Alcohol Dependence 2006, 83:233-37. CrossRef
  62. Tiffany ST, Carter BL: Is craving the source of compulsive drug use? / Journal of Psychopharmacology 1998, 12:23-0. CrossRef
  63. Kampman KM, Volpicelli JR, McGinnis DE, Alterman AI, Weinrieb RM, D'Angelo L, Epperson LE: Reliability and validity of the Cocaine Selective Severity Assessment. / Addictive Behaviors 1998, 23:449-61. CrossRef
  64. Heatherton TF, Kozlowski LT, Frecker RC, Fagerstrom K: The Fagerstrom test for nicotine dependence: a revision of the Fagerstrom tolerance questionnaire. / British Journal of Addiction 1999, 86:1119-127. CrossRef
  65. Kozlowski LT, Porter CQ, Orleans CT, Pope MA, Heatherton T: Predicting smoking cessation with self-reported measures of nicotine dependence: FTQ, FTND, and HIS. / Drug and Alcohol Dependence 1994, 34:211-16. CrossRef
  66. Rush AJ, Bernstein IH, Trivedi MH, Carmody TJ, Wisniewski S, Mundt JC, Shores-Wilson K, Biggs MM, Woo A, Nierenberg AA, Fava M: An evaluation of the quick inventory of depressive symptomatology and the Hamilton rating scale for depression: A sequenced treatment alternatives to relieve depression trial report. / Biological Psychiatry 2006, 59:493-01. CrossRef
  67. Rush AJ, Carmody TJ, Ibrahim HM, Trivedi MH, Biggs MM, Shores-Wilson K, Crismon ML, Toprac MG, Kashner TM: Comparison of self-report and clinician ratings on two inventories of depressive symptomatology. / Psychiatric Services 2008, 57:829-37. CrossRef
  68. Rush AJ, Carmody TJ, Reimitz PE: The Inventory of Depressive Symptomatology (IDS): Clinician (IDS-C) and Self-Report (SR) rating of depressive symptoms. / International Journal of Methods in Psychiatric Research 2000, 9:45-9. CrossRef
  69. Rush AJ, Trivedi MH, Ibrahim HM, Carmody TJ, Arnow B, Klein DN, Markoqitz JC, Ninan PT, Kornstein S, Manber R, Thase ME, Kocsis JH, Keller MB: The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. / Biological Psychiatry 2003, 54:573-83. CrossRef
  70. Trivedi MH, Rush AJ, Ibrahim HM, Carmody TJ, Biggs MM, Suppes T, Crismon ML, Shores-Wilson K, Toprac MG, Dennehy EB, Witte B, Kashner TM: The Inventory of Depressive Symptomatology, Clinician Rating (IDS-C) and Self-Report (IDS-SR), and the Quick Inventory of Depressive Symptomatology, Clinician Rating (QIDS-C) and Self-Report (QIDS-SR) in public sector patients with mood disorders, a psychometric evaluation. / Psychological Medicine 2004, 34:73-2. CrossRef
  71. Snaith RP, Hamilton M, Humayan A, Hargreaves D, Trigwell P: A scale for the assessment of hedonic tone: The Snaith-Hamilton Pleasure Scale. / British Journal of Psychiatry 1995, 167:99-03. CrossRef
  72. Endicott J, Nee J, Harrison W, Blumenthal R: Quality of Life Enjoyment and Satisfaction Questionnaire: a new measure. / Psychopharmacology Bulletin 1993, 29:321-26.
  73. Ware JE: Conceptualization and measurement of health-related quality of life: comments on an evolving field. / Archives of Physical Medicine and Rehabilitation 2003,84(4 Suppl 2):S43-1.
  74. Ware JE, Snow KK, Kosinski M, Gandek B: / SF-36 Health Survey Manual and Interpretation Guide. Boston: New England Medical Center, The Health Institute; 1993.
  75. Golden CJ: / Stroop Color and Word Test: A manual for clinical and experimental uses. Wood Dale: Stoelting Co; 1978.
  76. Stroop JR: Studies of interference in serial verbal reactions. / Journal of Experimental Psychology 1935, 18:643-62. CrossRef
  77. Fava M, Graves LM, Benazzi F, Scalia MJ, Iosifescu DV, Alpert JE, Papakostas GI: A cross-sectional study of the prevalence of cognitive and physical symptoms during long-term antidepressant treatment. / Journal of Clinical Psychiatry 2006, 67:1754-759. CrossRef
  78. Wechsler D: / Wechsler test of adult reading. San Antonio: Psychological Corporation; 2001.
  79. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A: American College of Sports Medicine; American Heart Association. Physical activity and public health: Updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. / Circulation 2007, 116:1081-093. CrossRef
  80. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A: Physical activity and public health: Updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. / Medicine & Science in Sports & Exercise 2007, 39:1423-434. CrossRef
  81. Pate RR, Pratt M, Blair SN, Haskell WL, Macera CA, Bouchard C, Buchner D, Ettinger W, Heath GW, King AC: Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. / Journal of the American Medical Association 1995, 273:402-07. CrossRef
  82. Nelson ME, Rejeski WJ, Blair SN, Duncan PW, Judge JO, King AC, Macera CA, Castaneda-Sceppa C: American College of Sports Medicine; American Heart Association. Physical activity and public health in older adults: Recommendation from the American College of Sports Medicine and the American Heart Association. / Circulation 2007, 116:1094-105. CrossRef
  83. Nelson ME, Rejeski WJ, Blair SN, Duncan PW, Judge JO, King AC, Macera CA, Castaneda-Sceppa C: Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. / Medicine & Science in Sports & Exercise 2007, 39:1435-445. CrossRef
  84. NIH Consensus Development Panel on Physical Activity and Cardiovascular Health: Physical activity and cardiovascular health. / Journal of the American Medical Association 1996, 276:241-46. CrossRef
  85. Fletcher GF, Balady G, Froelicher VF, Harley LH, Haskell WL, Pollock ML: Exercise standards. A statement for healthcare professionals from the American Heart Association. Writing Group. / Circulation 1995, 91:580-15.
  86. Smith SC, Blair SN, Criqui MH, Fletcher GF, Fuster V, Gersh BJ, Gotto AM, Gould KL, Greenland P, Grundy SM: AHA consensus panel statement. Preventing heart attack and death in patients with coronary disease. The Secondary Prevention Panel. / Journal of the American College of Cardiology 1995, 26:292-94. CrossRef
  87. US Department of Health and Human Services (USDHHS): Physical activity and health: A report of the Surgeon General. [http://www.cdc.gov/nccdphp/sgr/contents.htm] / US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion 1996.
  88. Blumenthal JA, Babyak MA, Doraiswamy PM, Watkins L, Hoffman BM, Barbour KA, Herman S, Craighead WE, Brosse AL, Waugh R, Hinderliter A, Sherwood A: Exercise and pharmacotherapy in the treatment of major depressive disorder. / Psychosomatic Medicine 2007, 69:587-96. CrossRef
  89. Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO: Exercise treatment for depression: Efficacy and dose response. / American Journal of Preventive Medicine 2005, 28:1-. CrossRef
  90. Veale D, Le Fevre K, Pantelis C, de Souza V, Mann A, Sargeant A: Aerobic exercise in the adjunctive treatment of depression: A randomized controlled trial. / Journal of the Royal Society of Medicine 1992, 85:541-44.
  91. Trivedi MH, Greer TL, Grannemann BD, Chambliss HO, Jordan AN: Exercise as an augmentation strategy for treatment of major depression. / Journal of Psychiatric Practice 2006, 12:205-13. CrossRef
  92. Chaouloff F: Effects of acute physical exercise on central serotonergic systems. / Medicine & Science in Sports & Exercise 1997, 29:58-2.
  93. Weicker H, Struder HK: Influence of exercise on serotonergic neuromodulation in the brain. / Journal of Amino Acids 2001, 20:35-7. CrossRef
  94. Wipfli B, Landers D, Nagoshi C, Ringenbach S: An examination of serotonin and psychological variables in the relationship between exercise and mental health. / Scandinavian Journal of Medicine & Science in Sports 2011, 21:474-81. CrossRef
  95. Sparling PB, Giuffrida A, Pilmelli D, Rosskopf L, Dietrich A: Exercise activates the endocannabinoid system. / NeuroReport 2003,14(17):2209-211. CrossRef
  96. Blumenthal JA, Emery CF, Walsh MA, Cox DR, Kuhn CM, Williams RB, WIlliams RS: Exercise training in healthy Type A middle-aged men: Effects on behavioral and cardiovascular responses. / Psychosomatic Medicine 1988,50(4):418.
  97. Blumenthal JA, Fredrikson M, Kuhn CM, Ulmer RL, Walsh-Riddle M, Appelbaum M: Aerobic exercise reduces levels of cardiovascular and sympathoadrenal responses to mental stress in subjects without prior evidence of myocardial isochemia. / American Journal of Cardiology 1990,65(1):93-8. CrossRef
  98. Seifert T, Brassard P, Wissenberg M, Rasmussen P, Nordby P, Stallknecht B, Adser H, Jakobsen AH, Pilegaard H, Nielsen HB, Secher NH: Endurance training enhances BDNF release from the human brain. / American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2010,298(2):R372..
  99. Smolander J, Blair SN, Kohl HW: Work ability, physical activity, and cardiorespiratory fitness: 2-year results from Project Active. / Journal of Occupational and Environmental Medicine 2000, 42:906-10. CrossRef
  100. Hien DA, Wells EA, Jiang H, Suarez-Morales L, Campbell AN, Cohen LR, Miele GM, Killeen T, Brigham GS, Zhang Y, Hansen C, Hodgkins C, Hatch-Maillette M, Brown C, Kulaga A, Kristman-Valente A, Chu M, Sage R, Robinson JA, Liu D, Nunes EV: Multisite randomized trial of behavioral interventions for women with co-occurring PTSD and substance use disorders. / Journal of Consulting and Clinical Psychology 2009, 77:607-19. CrossRef
  101. Pilkington K, Kirkwood G, Rampes H, Richardson J: Yoga for depression: The research evidence. / Journal of Addictive Disorders 2005, 89:13-4.
  102. Nunes EV, McGrath PJ, Quitkin FM, Ocepek-Welikson K, Stewart JW, Koenig T, Wager S, Klein DF: Imipramine treatment of cocaine abuse: Possible boundaries of efficacy. / Drug and Alcohol Dependence 1995, 39:185-95. CrossRef
  103. Nunes EV, Quitkin FM, Donovan SJ, Deliyannides D, Ocepek-Welikson K, Koenig T, Brady R, McGrath PJ, Woody GE: Imipramine treatment of opiate-dependent patients with depressive disorders. A placebo-controlled trial. / Archives of General Psychiatry 1998, 55:153-60. CrossRef
  104. Magura S, Kang SY: Validity of self-reported drug use in high risk populations: a metaanalytical review. / Substance Use and Misuse 1996, 31:1131-153. CrossRef
  105. Hersh D, Mulgrew CL, Van Kirk J, Kranzler HR: The validity of self-reported cocaine use in two groups of cocaine abusers. / Journal of Consulting and Clinical Psychology 1999, 67:37-2. CrossRef
  106. Morgan PT, Malison RT: Cocaine and sleep: early abstinence. / TheScientificWorldJournal 2007, 7:223-30. CrossRef
  107. Valladares EM, Irwin MR: Polysomnographic sleep dysregulation in cocaine dependence. / TheScientificWorldJournal 2007, 7:213-16. CrossRef
  108. Rounsaville BJ, Anton SF, Carroll KM, Budde D, Prusoff BA, Gawin F: Psychiatric diagnoses of treatment-seeking cocaine abusers. / Archives of General Psychiatry 1991,48(1):43-1.
  109. Kubitz K, Landers D, Petruzzello S, Han M: The effects of acute and chronic exercise on sleep. A meta-analytic review. / Sports Medicine 1996,21(4):277-91. CrossRef
  110. Hillman C, Erickson K, Kramer A: Be smart, exercise your heart: exercise effects on brain and cognition. / Nature Reviews Neuroscience 2008,9(1):58-5. CrossRef
  111. Rethorst CD, Wipfli BM, Landers DM: The antidepressive effects of exercise. / Sports Medicine 2009,39(6):491-11. CrossRef
  112. Wipfli BM, Rethorst CD, Landers DM: The anxiolytic effects of exercise: a meta-analysis of randomized trials and dose-response analysis. / Journal of Sport & Exercise Psychology 2008,30(4):392-10.
  113. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC: The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. / Journal of Clinical Psychiatry 1998,59(Suppl 20):22-3. quiz 34-7
  114. Fals-Stewart W, O'Farrell TJ, Freitas TT, McFarlin SK, Rutigliano P: The timeline followback reports of psychoactive substance use by drug-abusing patients: psychometric properties. / Journal of Consulting and Clinical Psychology 2000, 68:134-44. CrossRef
  115. Paliwal P, Hyman SM, Sinha R: Craving predicts time to cocaine relapse: Further validation of the now and brief versions of the cocaine craving questionnaire. / Drug and Alcohol Dependence 2008, 93:252-59. CrossRef
  116. Cacciola JS, Alterman AI, McLellan AT: Initial evidence for the reliability and validity of a "Lite" version of the Addiction Severity Index. / Drug and Alcohol Dependence 2007, 87:297-02. CrossRef
  117. Franken IHA, Rassin E, Muris P: The assessment of ahedonia in clinical and non-clinical populations: Further validation of the Snaith-Hamilton pleasure scale (SHAPS). / Journal of Affective Disorders 2007, 99:83-9. CrossRef
  118. Wyrwich K, Harnam N, Revicki DA, Locklear JC, Svedsater H, Endicott J: Assessing health-related quality of life in generalized anxiety disorder using the Quality of Life Enjoyment and Satisfaction Questionnaire. / International Clinical Psychopharmacology 2009, 24:289-95. CrossRef
  119. Rapaport MH, Clary C, Fayyad R, Endicott J: Quality-of-life impairment in depressive and anxiety disorders. / American Journal of Psychiatry 2005, 62:1171-178. CrossRef
  120. Fava M, Iosifescu DV, Pedrelli P, Baer L: Reliability and validity of the Massachusetts general hospital cognitive and physical functioning questionnaire. / Psychotherapy and Psychosomatics 2009, 78:91-7. CrossRef
  
• 作者单位：Madhukar H Trivedi (1)
  Tracy L Greer (1)
  Bruce D Grannemann (1)
  Timothy S Church (2)
  Eugene Somoza (3)
  Steven N Blair (4) (5)
  Jose Szapocznik (6)
  Mark Stoutenberg (6)
  Chad Rethorst (1)
  Diane Warden (1)
  Kolette M Ring (1)
  Robrina Walker (1)
  David W Morris (1)
  Andrzej S Kosinski (7)
  Tiffany Kyle (8)
  Bess Marcus (9)
  Becca Crowell (10)
  Neal Oden (11)
  Edward Nunes (12)
  
  1. The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas, 75390-9119, USA
  2. Preventive Medicine Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA, 70808, USA
  3. Cincinnati Addictions Research Center (CinARC); Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson St, Cincinnati, OH, 45219, USA
  4. Department of Exercise Science, University of South Carolina, 514 Main Street, Columbia, SC, 29208, USA
  5. Department of Epidemiology and Biostatistics, University of South Carolina, 800 Sumter Street, Columbia, SC, 29208, USA
  6. Department of Epidemiology and Public Health, University of Miami, Miller School of Medicine, 1120 NW 14th Street, Miami, 33136, FL, USA
  7. Department of Biostatistics and Bioinformatics, Duke University Medical Center, Duke Clinical Research Institute, P. O. Box 17969, Durham, NC, 27715, USA
  8. The Center for Drug-Free Living, 3670 Maguire Boulevard, Orlando, FL, 32853, USA
  9. Department of Family and Preventive Medicine, The University of California, San Diego, 9500 Gilman Drive, 0622, La Jolla, California, 92093-0622, USA
  10. Nexus Recovery Center, Inc, 8733 La Prada Dr, Dallas, Texas, 75228, USA
  11. The EMMES Corporation, 401 N. Washington St, Rockville, MD, 20850, USA
  12. New York State Psychiatric Institute/Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 69, New York, NY, 10032, USA
  

文摘

Background There is a need for novel approaches to the treatment of stimulant abuse and dependence. Clinical data examining the use of exercise as a treatment for the abuse of nicotine, alcohol, and other substances suggest that exercise may be a beneficial treatment for stimulant abuse, with direct effects on decreased use and craving. In addition, exercise has the potential to improve other health domains that may be adversely affected by stimulant use or its treatment, such as sleep disturbance, cognitive function, mood, weight gain, quality of life, and anhedonia, since it has been shown to improve many of these domains in a number of other clinical disorders. Furthermore, neurobiological evidence provides plausible mechanisms by which exercise could positively affect treatment outcomes. The current manuscript presents the rationale, design considerations, and study design of the National Institute on Drug Abuse (NIDA) Clinical Trials Network (CTN) CTN-0037 Stimulant Reduction Intervention using Dosed Exercise (STRIDE) study. Methods/Design STRIDE is a multisite randomized clinical trial that compares exercise to health education as potential treatments for stimulant abuse or dependence. This study will evaluate individuals diagnosed with stimulant abuse or dependence who are receiving treatment in a residential setting. Three hundred and thirty eligible and interested participants who provide informed consent will be randomized to one of two treatment arms: Vigorous Intensity High Dose Exercise Augmentation (DEI) or Health Education Intervention Augmentation (HEI). Both groups will receive TAU (i.e., usual care). The treatment arms are structured such that the quantity of visits is similar to allow for equivalent contact between groups. In both arms, participants will begin with supervised sessions 3 times per week during the 12-week acute phase of the study. Supervised sessions will be conducted as one-on-one (i.e., individual) sessions, although other participants may be exercising at the same time. Following the 12-week acute phase, participants will begin a 6-month continuation phase during which time they will attend one weekly supervised DEI or HEI session. Clinical Trials Registry ClinicalTrials.gov, NCT01141608 http://clinicaltrials.gov/ct2/show/NCT01141608?term=Stimulant+Reduction+Intervention+using+Dosed+Exercise&rank=1